The Great Debate at 'Immunotherapy Bridge', Naples, December 5, 2019

Paolo A. Ascierto; Carlo Bifulco; Jerome Galon; Claus Garbe; Samir N. Khleif; Jennifer McQuade; Kunle Odunsi; Hideho Okada; Chrystal M. Paulos; Sergio A. Quezada; Hussein A. Tawbi; John Timmerman; Giorgio Trinchieri; Lisa H. Butterfield; Igor Puzanov

doi:10.1136/jitc-2020-000921

The Great Debate at 'Immunotherapy Bridge', Naples, December 5, 2019

Paolo A. Ascierto, Carlo Bifulco, Jerome Galon, Claus Garbe, Samir N. Khleif, Jennifer McQuade, Kunle Odunsi, Hideho Okada, Chrystal M. Paulos, Sergio A. Quezada, Hussein A. Tawbi, John Timmerman, Giorgio Trinchieri, Lisa H. Butterfield, Igor Puzanov

Melanoma Medical Oncology

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

As part of the 2019 Immunotherapy Bridge congress (December 4-5, Naples, Italy), the Great Debate session featured counterpoint views from leading experts on six topical issues in immunotherapy today. These were the use of chimeric antigen receptor T cell therapy in solid tumors, whether the Immunoscore should be more widely used in clinical practice, whether antibody-dependent cellular cytotoxicity is important in the mode of action of anticytotoxic T-lymphocyte-associated protein 4 antibodies, whether the brain is immunologically unique or just another organ, the role of microbiome versus nutrition in affecting responses to immunotherapy, and whether chemotherapy is immunostimulatory or immunosuppressive. Discussion of these important topics are summarized in this report.

Original language	English (US)
Article number	e000921
Journal	Journal for immunotherapy of cancer
Volume	8
Issue number	2
DOIs	https://doi.org/10.1136/jitc-2020-000921
State	Published - Aug 24 2020

Keywords

CTLA-4 antigen
chimeric antigen
cytotoxicity
immunologic
immunotherapy
receptors

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Molecular Medicine
Oncology
Pharmacology
Cancer Research

Access to Document

10.1136/jitc-2020-000921

Cite this

Ascierto, P. A., Bifulco, C., Galon, J., Garbe, C., Khleif, S. N., McQuade, J., Odunsi, K., Okada, H., Paulos, C. M., Quezada, S. A., Tawbi, H. A., Timmerman, J., Trinchieri, G., Butterfield, L. H., & Puzanov, I. (2020). The Great Debate at 'Immunotherapy Bridge', Naples, December 5, 2019. Journal for immunotherapy of cancer, 8(2), Article e000921. https://doi.org/10.1136/jitc-2020-000921

@article{1b52bae2c4f24770b5c0acf298f0c9ff,

title = "The Great Debate at 'Immunotherapy Bridge', Naples, December 5, 2019",

abstract = "As part of the 2019 Immunotherapy Bridge congress (December 4-5, Naples, Italy), the Great Debate session featured counterpoint views from leading experts on six topical issues in immunotherapy today. These were the use of chimeric antigen receptor T cell therapy in solid tumors, whether the Immunoscore should be more widely used in clinical practice, whether antibody-dependent cellular cytotoxicity is important in the mode of action of anticytotoxic T-lymphocyte-associated protein 4 antibodies, whether the brain is immunologically unique or just another organ, the role of microbiome versus nutrition in affecting responses to immunotherapy, and whether chemotherapy is immunostimulatory or immunosuppressive. Discussion of these important topics are summarized in this report.",

keywords = "CTLA-4 antigen, chimeric antigen, cytotoxicity, immunologic, immunotherapy, receptors",

author = "Ascierto, {Paolo A.} and Carlo Bifulco and Jerome Galon and Claus Garbe and Khleif, {Samir N.} and Jennifer McQuade and Kunle Odunsi and Hideho Okada and Paulos, {Chrystal M.} and Quezada, {Sergio A.} and Tawbi, {Hussein A.} and John Timmerman and Giorgio Trinchieri and Butterfield, {Lisa H.} and Igor Puzanov",

note = "Publisher Copyright: {\textcopyright} ",

year = "2020",

month = aug,

day = "24",

doi = "10.1136/jitc-2020-000921",

language = "English (US)",

volume = "8",

journal = "Journal for immunotherapy of cancer",

issn = "2051-1426",

publisher = "BioMed Central",

number = "2",

}

TY - JOUR

T1 - The Great Debate at 'Immunotherapy Bridge', Naples, December 5, 2019

AU - Ascierto, Paolo A.

AU - Bifulco, Carlo

AU - Galon, Jerome

AU - Garbe, Claus

AU - Khleif, Samir N.

AU - McQuade, Jennifer

AU - Odunsi, Kunle

AU - Okada, Hideho

AU - Paulos, Chrystal M.

AU - Quezada, Sergio A.

AU - Tawbi, Hussein A.

AU - Timmerman, John

AU - Trinchieri, Giorgio

AU - Butterfield, Lisa H.

AU - Puzanov, Igor

N1 - Publisher Copyright: ©

PY - 2020/8/24

Y1 - 2020/8/24

N2 - As part of the 2019 Immunotherapy Bridge congress (December 4-5, Naples, Italy), the Great Debate session featured counterpoint views from leading experts on six topical issues in immunotherapy today. These were the use of chimeric antigen receptor T cell therapy in solid tumors, whether the Immunoscore should be more widely used in clinical practice, whether antibody-dependent cellular cytotoxicity is important in the mode of action of anticytotoxic T-lymphocyte-associated protein 4 antibodies, whether the brain is immunologically unique or just another organ, the role of microbiome versus nutrition in affecting responses to immunotherapy, and whether chemotherapy is immunostimulatory or immunosuppressive. Discussion of these important topics are summarized in this report.

AB - As part of the 2019 Immunotherapy Bridge congress (December 4-5, Naples, Italy), the Great Debate session featured counterpoint views from leading experts on six topical issues in immunotherapy today. These were the use of chimeric antigen receptor T cell therapy in solid tumors, whether the Immunoscore should be more widely used in clinical practice, whether antibody-dependent cellular cytotoxicity is important in the mode of action of anticytotoxic T-lymphocyte-associated protein 4 antibodies, whether the brain is immunologically unique or just another organ, the role of microbiome versus nutrition in affecting responses to immunotherapy, and whether chemotherapy is immunostimulatory or immunosuppressive. Discussion of these important topics are summarized in this report.

KW - CTLA-4 antigen

KW - chimeric antigen

KW - cytotoxicity

KW - immunologic

KW - immunotherapy

KW - receptors

UR - http://www.scopus.com/inward/record.url?scp=85089923386&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85089923386&partnerID=8YFLogxK

U2 - 10.1136/jitc-2020-000921

DO - 10.1136/jitc-2020-000921

M3 - Article

C2 - 32843491

AN - SCOPUS:85089923386

SN - 2051-1426

VL - 8

JO - Journal for immunotherapy of cancer

JF - Journal for immunotherapy of cancer

IS - 2

M1 - e000921

ER -

The Great Debate at 'Immunotherapy Bridge', Naples, December 5, 2019

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this