TY - JOUR
T1 - The haematopoietic cell transplantation comorbidity index score is predictive of early death and survival in patients over 60 years of age receiving induction therapy for acute myeloid leukaemia
AU - Giles, Francis J.
AU - Borthakur, Gautam
AU - Ravandi, Farhad
AU - Faderl, Stefan
AU - Verstovsek, Srdan
AU - Thomas, Deborah
AU - Wierda, William
AU - Ferrajoli, Alessandra
AU - Kornblau, Steven
AU - Pierce, Sherry
AU - Albitar, Maher
AU - Cortes, Jorge
AU - Kantarjian, Hagop
N1 - Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2007/2
Y1 - 2007/2
N2 - The haematopoietic cell transplantation comorbidity index (HCTCI) predicts nonrelapse mortality and overall survival (OS) post-stem cell transplantation. HCTCI scores were assessed in 177 patients over 60 years of age receiving acute myeloid leukaemia (AML) induction therapy. HCTCI score was 0 in 22% of patients, 1-2 in 30%, and ≥3 in 48%. In patients with scores of 0, 1-2, or ≥3, early death rates were 3%, 11% and 29% (P < 0.001) respectively; median OS was 45, 31 and 19 weeks (P = 0.04) respectively. The HCTCI score is predictive of early death rates and OS in older patients receiving AML induction therapy.
AB - The haematopoietic cell transplantation comorbidity index (HCTCI) predicts nonrelapse mortality and overall survival (OS) post-stem cell transplantation. HCTCI scores were assessed in 177 patients over 60 years of age receiving acute myeloid leukaemia (AML) induction therapy. HCTCI score was 0 in 22% of patients, 1-2 in 30%, and ≥3 in 48%. In patients with scores of 0, 1-2, or ≥3, early death rates were 3%, 11% and 29% (P < 0.001) respectively; median OS was 45, 31 and 19 weeks (P = 0.04) respectively. The HCTCI score is predictive of early death rates and OS in older patients receiving AML induction therapy.
KW - Acute myeloid leukaemia
KW - Comorbidity
KW - Induction chemotherapy
KW - Prognosis
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U2 - 10.1111/j.1365-2141.2006.06476.x
DO - 10.1111/j.1365-2141.2006.06476.x
M3 - Article
C2 - 17223919
AN - SCOPUS:33846433493
SN - 0007-1048
VL - 136
SP - 624
EP - 627
JO - British Journal of Haematology
JF - British Journal of Haematology
IS - 4
ER -