Abstract
We showed that the HER2/Grb2/Akt pathway induces all-trans retinoic acid (ATRA) resistance in breast cancer cells by suppressing the DNA binding activity of retinoic acid receptors (RAR). AP-1 activation was shown to induce ATRA resistance- Here, we determined whether AP-1 binding activity is correlated with ATRA resistance in HER2-overexpressing cells. Inhibition of HER2/Grb2/Akt decreased AP-1 binding activity in HER2-transfected cells, but increased AP-1 activity in cells that are naturally HER2-overexpressing. Since HER2/Grb2/Akt inhibition sensitized both cell types to ATRA, our results indicate that, unlike RAR, AP-1 binding activity is not correlated with ATRA sensitivity in HER2-overexpressing breast cancer cells.
Original language | English (US) |
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Pages (from-to) | 903-908 |
Number of pages | 6 |
Journal | Oncology reports |
Volume | 12 |
Issue number | 4 |
DOIs | |
State | Published - Oct 2004 |
Keywords
- Akt
- AP-1
- Grb2
- HER2
ASJC Scopus subject areas
- Oncology
- Cancer Research