TY - JOUR
T1 - The immune system and opiate withdrawal
AU - Dafny, N.
AU - Dougherty, P. M.
AU - Pellis, N. R.
N1 - Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 1989
Y1 - 1989
N2 - Whole body exposure to 500 rad ionizing irradiation suppresses the immune system in rats. Moreover, when administered prior to chronic morphine treatment, irradiation exposure also dramatically reduces the severity of naloxone-precipitated withdrawal in morphine dependent animals. The reinstillment of 2-6 × 108 normal lymphoid immunocompetent cells to irradiated rats by adoptive transfer prior to chronic morphine treatment restores all withdrawal signs precipiated by naloxone injection. The data suggest that specific cellular activities or factors derived from lymphoid cells are required for the expression of opiate withdrawal, indicating that the immune system participates in the manifestation of opiate dependence.
AB - Whole body exposure to 500 rad ionizing irradiation suppresses the immune system in rats. Moreover, when administered prior to chronic morphine treatment, irradiation exposure also dramatically reduces the severity of naloxone-precipitated withdrawal in morphine dependent animals. The reinstillment of 2-6 × 108 normal lymphoid immunocompetent cells to irradiated rats by adoptive transfer prior to chronic morphine treatment restores all withdrawal signs precipiated by naloxone injection. The data suggest that specific cellular activities or factors derived from lymphoid cells are required for the expression of opiate withdrawal, indicating that the immune system participates in the manifestation of opiate dependence.
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U2 - 10.1016/0192-0561(89)90083-0
DO - 10.1016/0192-0561(89)90083-0
M3 - Article
C2 - 2674032
AN - SCOPUS:0024412022
SN - 0192-0561
VL - 11
SP - 371
EP - 375
JO - International Journal of Immunopharmacology
JF - International Journal of Immunopharmacology
IS - 4
ER -