TY - JOUR
T1 - The impact of Helicobacter pylori on EGF, EGF receptor, and the c-erb-B2 expression
AU - Jurkowska, Grazyna
AU - Piotrowska-Staworko, Grazyna
AU - Guzińska-Ustymowicz, Katarzyna
AU - Kemona, Andrzej
AU - ͆widnicka-Siergiejko, Agnieszka
AU - Łaszewicz, Wiktor
AU - Da¸browski, Andrzej
N1 - Publisher Copyright:
© 2014 Medical University of Bialystok. Published by Elsevier Urban & Partner Sp. z o.o. All rights reserved.
PY - 2014/9/1
Y1 - 2014/9/1
N2 - Purpose: Increased expression of epidermal growth factor (EGF), its receptor (EGFR), and c-erb-B2 protein, which is homological with the EGF receptor, in gastric mucosa, may play a role in gastric carcinogenesis. We assessed if the infection and eradication of Helicobacter pylori (H. pylori) affects the gastric expression of growth factors and serum gastrin concentrations. Patients/methods: We examined immunohistochemically gastric EGF and both receptors' expression in: gastric cancer (GC; n = 29), chronic gastritis with H. pylori infection (GHp+; n = 40) before and after eradication and in patients without H. pylori infection (GHp-; n = 42). Results: Before the eradication therapy, gastric mucosal EGF and both receptor's expressions in GHp+ patients were increased compared to GHp- ( p < 0.05), but were similar to GC. After eradication, EGF and the receptor's expression significantly decreased in the gastric body. Both EGFR and c-erb-B2 expression in the antrum were still higher than in GHp- (p < 0.05), and remained comparable to GC. Conclusions: In patients with H. pylori infection the gastric mucosal EGF, EGFR, and c-erb-B2 expressions are similar to those observed in gastric cancer. The persistence of the antral expression of receptors after eradication, at a level comparable to the gastric cancer group, suggests their eventual role in the progression of changes initiated by H. pylori toward carcinogenesis.
AB - Purpose: Increased expression of epidermal growth factor (EGF), its receptor (EGFR), and c-erb-B2 protein, which is homological with the EGF receptor, in gastric mucosa, may play a role in gastric carcinogenesis. We assessed if the infection and eradication of Helicobacter pylori (H. pylori) affects the gastric expression of growth factors and serum gastrin concentrations. Patients/methods: We examined immunohistochemically gastric EGF and both receptors' expression in: gastric cancer (GC; n = 29), chronic gastritis with H. pylori infection (GHp+; n = 40) before and after eradication and in patients without H. pylori infection (GHp-; n = 42). Results: Before the eradication therapy, gastric mucosal EGF and both receptor's expressions in GHp+ patients were increased compared to GHp- ( p < 0.05), but were similar to GC. After eradication, EGF and the receptor's expression significantly decreased in the gastric body. Both EGFR and c-erb-B2 expression in the antrum were still higher than in GHp- (p < 0.05), and remained comparable to GC. Conclusions: In patients with H. pylori infection the gastric mucosal EGF, EGFR, and c-erb-B2 expressions are similar to those observed in gastric cancer. The persistence of the antral expression of receptors after eradication, at a level comparable to the gastric cancer group, suggests their eventual role in the progression of changes initiated by H. pylori toward carcinogenesis.
KW - Epidermal growth factor
KW - Epidermal growth factor receptor
KW - Helicobacter pylori infection
KW - c-erB-2 protein
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U2 - 10.1016/j.advms.2014.01.006
DO - 10.1016/j.advms.2014.01.006
M3 - Article
C2 - 25051417
AN - SCOPUS:84908460864
SN - 1896-1126
VL - 59
SP - 221
EP - 226
JO - Advances in medical sciences
JF - Advances in medical sciences
IS - 2
ER -