The Impact of Immunotherapy on Sleep and Circadian Rhythms in Patients with Cancer

Diwakar D. Balachandran; Lara Bashoura; Ajay Sheshadri; Ellen Manzullo; Saadia A. Faiz

doi:10.3389/fonc.2023.1295267

The Impact of Immunotherapy on Sleep and Circadian Rhythms in Patients with Cancer

Diwakar D. Balachandran, Lara Bashoura, Ajay Sheshadri, Ellen Manzullo, Saadia A. Faiz

Research output: Contribution to journal › Short survey › peer-review

Abstract

Immunotherapy has revolutionized treatments for both early and advanced cancers, and as their role evolves, their impact on sleep and circadian rhythms continues to unfold. The recognition, evaluation, and treatment of sleep and circadian rhythm disturbance leads to improved symptom management, quality of life and treatment outcomes. An intricate complex relationship exists in the microenvironment with immunity, sleep and the tumor, and these may further vary based on the cancer, addition of standard chemotherapy, and pre-existing patient factors. Sleep and circadian rhythms may offer tools to better utilize immunotherapy in the care of cancer patients, leading to better treatment outcome, reduced symptom burden, and increased quality of life.

Original language	English (US)
Article number	1295267
Journal	Frontiers in Oncology
Volume	13
DOIs	https://doi.org/10.3389/fonc.2023.1295267
State	Published - 2023

Keywords

circadian rhythm
immune checkpoint inhibitors
immunity
immunotherapy
sleep

ASJC Scopus subject areas

Oncology
Cancer Research

Access to Document

10.3389/fonc.2023.1295267

Cite this

@article{cac421a2848b4927b04bc0239364d417,

title = "The Impact of Immunotherapy on Sleep and Circadian Rhythms in Patients with Cancer",

abstract = "Immunotherapy has revolutionized treatments for both early and advanced cancers, and as their role evolves, their impact on sleep and circadian rhythms continues to unfold. The recognition, evaluation, and treatment of sleep and circadian rhythm disturbance leads to improved symptom management, quality of life and treatment outcomes. An intricate complex relationship exists in the microenvironment with immunity, sleep and the tumor, and these may further vary based on the cancer, addition of standard chemotherapy, and pre-existing patient factors. Sleep and circadian rhythms may offer tools to better utilize immunotherapy in the care of cancer patients, leading to better treatment outcome, reduced symptom burden, and increased quality of life.",

keywords = "circadian rhythm, immune checkpoint inhibitors, immunity, immunotherapy, sleep",

author = "Balachandran, {Diwakar D.} and Lara Bashoura and Ajay Sheshadri and Ellen Manzullo and Faiz, {Saadia A.}",

note = "Publisher Copyright: Copyright {\textcopyright} 2023 Balachandran, Bashoura, Sheshadri, Manzullo and Faiz.",

year = "2023",

doi = "10.3389/fonc.2023.1295267",

language = "English (US)",

volume = "13",

journal = "Frontiers in Oncology",

issn = "2234-943X",

publisher = "Frontiers Media S. A.",

}

TY - JOUR

T1 - The Impact of Immunotherapy on Sleep and Circadian Rhythms in Patients with Cancer

AU - Balachandran, Diwakar D.

AU - Bashoura, Lara

AU - Sheshadri, Ajay

AU - Manzullo, Ellen

AU - Faiz, Saadia A.

PY - 2023

Y1 - 2023

N2 - Immunotherapy has revolutionized treatments for both early and advanced cancers, and as their role evolves, their impact on sleep and circadian rhythms continues to unfold. The recognition, evaluation, and treatment of sleep and circadian rhythm disturbance leads to improved symptom management, quality of life and treatment outcomes. An intricate complex relationship exists in the microenvironment with immunity, sleep and the tumor, and these may further vary based on the cancer, addition of standard chemotherapy, and pre-existing patient factors. Sleep and circadian rhythms may offer tools to better utilize immunotherapy in the care of cancer patients, leading to better treatment outcome, reduced symptom burden, and increased quality of life.

AB - Immunotherapy has revolutionized treatments for both early and advanced cancers, and as their role evolves, their impact on sleep and circadian rhythms continues to unfold. The recognition, evaluation, and treatment of sleep and circadian rhythm disturbance leads to improved symptom management, quality of life and treatment outcomes. An intricate complex relationship exists in the microenvironment with immunity, sleep and the tumor, and these may further vary based on the cancer, addition of standard chemotherapy, and pre-existing patient factors. Sleep and circadian rhythms may offer tools to better utilize immunotherapy in the care of cancer patients, leading to better treatment outcome, reduced symptom burden, and increased quality of life.

KW - circadian rhythm

KW - immune checkpoint inhibitors

KW - immunity

KW - immunotherapy

KW - sleep

UR - http://www.scopus.com/inward/record.url?scp=85179310588&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85179310588&partnerID=8YFLogxK

U2 - 10.3389/fonc.2023.1295267

DO - 10.3389/fonc.2023.1295267

M3 - Short survey

C2 - 38090501

AN - SCOPUS:85179310588

SN - 2234-943X

VL - 13

JO - Frontiers in Oncology

JF - Frontiers in Oncology

M1 - 1295267

ER -

The Impact of Immunotherapy on Sleep and Circadian Rhythms in Patients with Cancer

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this