The impact of intraoperative opioid use on survival after oral cancer surgery

Miguel A. Patino; Rafael E. Ramirez; Carlos A. Perez; Lei Feng; Pranav Kataria; Jeffrey Myers; Juan P. Cata

doi:10.1016/j.oraloncology.2017.09.006

The impact of intraoperative opioid use on survival after oral cancer surgery

Miguel A. Patino, Rafael E. Ramirez, Carlos A. Perez, Lei Feng, Pranav Kataria, Jeffrey Myers, Juan P. Cata

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

Objectives To investigate the impact of opioid use on cancer recurrence after oral cancer surgery. We hypothesized that the amount of opioids administered during oral cancer surgery is an independent predictor of recurrence free survival (RFS) and overall survival (OS). Methods After Institutional Review Board approval, we collected demographic, tumor related, intraoperative and survival data of patients who had oral cancer surgery. Multivariable Cox proportional hazards models were used to determine the impact of important covariates on RFS and OS. Results 268 patients were included. After adjusting for significant covariates, the amount of opioids administered during surgery was not an independent predictor of RFS (HR: 1.27 [CI 95%, 0.838–1.924], p = 0.26). However, we observed an association between opioid consumption and shorter OS (HR = 1.77, [CI 95% = 0.995–3.149]. p = 0.05). Conclusions High requirements of opioids during surgery increase the risk of recurrence and mortality by 27% and 77%, although the association is not statically significant.

Original language	English (US)
Pages (from-to)	1-7
Number of pages	7
Journal	Oral Oncology
Volume	74
DOIs	https://doi.org/10.1016/j.oraloncology.2017.09.006
State	Published - Nov 2017

Keywords

Cancer recurrence
Opioids
Oral cancer
Surgery

ASJC Scopus subject areas

Oral Surgery
Oncology
Cancer Research

MD Anderson CCSG core facilities

Biostatistics Resource Group

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10.1016/j.oraloncology.2017.09.006

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title = "The impact of intraoperative opioid use on survival after oral cancer surgery",

abstract = "Objectives To investigate the impact of opioid use on cancer recurrence after oral cancer surgery. We hypothesized that the amount of opioids administered during oral cancer surgery is an independent predictor of recurrence free survival (RFS) and overall survival (OS). Methods After Institutional Review Board approval, we collected demographic, tumor related, intraoperative and survival data of patients who had oral cancer surgery. Multivariable Cox proportional hazards models were used to determine the impact of important covariates on RFS and OS. Results 268 patients were included. After adjusting for significant covariates, the amount of opioids administered during surgery was not an independent predictor of RFS (HR: 1.27 [CI 95%, 0.838–1.924], p = 0.26). However, we observed an association between opioid consumption and shorter OS (HR = 1.77, [CI 95% = 0.995–3.149]. p = 0.05). Conclusions High requirements of opioids during surgery increase the risk of recurrence and mortality by 27% and 77%, although the association is not statically significant.",

keywords = "Cancer recurrence, Opioids, Oral cancer, Surgery",

author = "Patino, {Miguel A.} and Ramirez, {Rafael E.} and Perez, {Carlos A.} and Lei Feng and Pranav Kataria and Jeffrey Myers and Cata, {Juan P.}",

note = "Publisher Copyright: {\textcopyright} 2017 Elsevier Ltd",

year = "2017",

month = nov,

doi = "10.1016/j.oraloncology.2017.09.006",

language = "English (US)",

volume = "74",

pages = "1--7",

journal = "Oral Oncology",

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TY - JOUR

T1 - The impact of intraoperative opioid use on survival after oral cancer surgery

AU - Patino, Miguel A.

AU - Ramirez, Rafael E.

AU - Perez, Carlos A.

AU - Feng, Lei

AU - Kataria, Pranav

AU - Myers, Jeffrey

AU - Cata, Juan P.

PY - 2017/11

Y1 - 2017/11

N2 - Objectives To investigate the impact of opioid use on cancer recurrence after oral cancer surgery. We hypothesized that the amount of opioids administered during oral cancer surgery is an independent predictor of recurrence free survival (RFS) and overall survival (OS). Methods After Institutional Review Board approval, we collected demographic, tumor related, intraoperative and survival data of patients who had oral cancer surgery. Multivariable Cox proportional hazards models were used to determine the impact of important covariates on RFS and OS. Results 268 patients were included. After adjusting for significant covariates, the amount of opioids administered during surgery was not an independent predictor of RFS (HR: 1.27 [CI 95%, 0.838–1.924], p = 0.26). However, we observed an association between opioid consumption and shorter OS (HR = 1.77, [CI 95% = 0.995–3.149]. p = 0.05). Conclusions High requirements of opioids during surgery increase the risk of recurrence and mortality by 27% and 77%, although the association is not statically significant.

AB - Objectives To investigate the impact of opioid use on cancer recurrence after oral cancer surgery. We hypothesized that the amount of opioids administered during oral cancer surgery is an independent predictor of recurrence free survival (RFS) and overall survival (OS). Methods After Institutional Review Board approval, we collected demographic, tumor related, intraoperative and survival data of patients who had oral cancer surgery. Multivariable Cox proportional hazards models were used to determine the impact of important covariates on RFS and OS. Results 268 patients were included. After adjusting for significant covariates, the amount of opioids administered during surgery was not an independent predictor of RFS (HR: 1.27 [CI 95%, 0.838–1.924], p = 0.26). However, we observed an association between opioid consumption and shorter OS (HR = 1.77, [CI 95% = 0.995–3.149]. p = 0.05). Conclusions High requirements of opioids during surgery increase the risk of recurrence and mortality by 27% and 77%, although the association is not statically significant.

KW - Cancer recurrence

KW - Opioids

KW - Oral cancer

KW - Surgery

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SN - 1368-8375

VL - 74

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JO - Oral Oncology

JF - Oral Oncology

ER -

The impact of intraoperative opioid use on survival after oral cancer surgery

Abstract

Keywords

ASJC Scopus subject areas

MD Anderson CCSG core facilities

Access to Document

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