The influence of a new analgetic-antiphlogistic compound (2-(2-methyl-3′chloro)-anilino-nicotinic acid) on platelet function and fibrinolytic activity in vitro

K. Widmer; R. C. Reed; E. J. Freireich

doi:10.1016/0049-3848(75)90146-2

The influence of a new analgetic-antiphlogistic compound (2-(2-methyl-3′chloro)-anilino-nicotinic acid) on platelet function and fibrinolytic activity in vitro

K. Widmer, R. C. Reed, E. J. Freireich

Leukemia

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

The effect of a new analgetic, Clonixin, on platelet function, clot retraction and fibrinolysis was studied in vitro. In Born's photometric technique platelet aggregation was inhibited starting at a Clonixin concentration of 1×10^-7M. The inhibition is strongly dose dependent and involves mostly secondary aggregation. An inhibition of clot retraction was seen only at higher concentrations (1×10^-4M) of Clonixin. This is a rather striking effect for an analgeticantiphlogistic compound. Fibrinolysis was unaffected at the concentrations tested.

Original language	English (US)
Pages (from-to)	9-17
Number of pages	9
Journal	Thrombosis Research
Volume	6
Issue number	1
DOIs	https://doi.org/10.1016/0049-3848(75)90146-2
State	Published - Jan 1975

ASJC Scopus subject areas

Hematology

Access to Document

10.1016/0049-3848(75)90146-2

Cite this

@article{c70a81c2e415409c9cf29d1c7526ea96,

title = "The influence of a new analgetic-antiphlogistic compound (2-(2-methyl-3′chloro)-anilino-nicotinic acid) on platelet function and fibrinolytic activity in vitro",

abstract = "The effect of a new analgetic, Clonixin, on platelet function, clot retraction and fibrinolysis was studied in vitro. In Born's photometric technique platelet aggregation was inhibited starting at a Clonixin concentration of 1×10-7M. The inhibition is strongly dose dependent and involves mostly secondary aggregation. An inhibition of clot retraction was seen only at higher concentrations (1×10-4M) of Clonixin. This is a rather striking effect for an analgeticantiphlogistic compound. Fibrinolysis was unaffected at the concentrations tested.",

author = "K. Widmer and Reed, {R. C.} and Freireich, {E. J.}",

year = "1975",

month = jan,

doi = "10.1016/0049-3848(75)90146-2",

language = "English (US)",

volume = "6",

pages = "9--17",

journal = "Thrombosis Research",

issn = "0049-3848",

publisher = "Elsevier Limited",

number = "1",

}

TY - JOUR

T1 - The influence of a new analgetic-antiphlogistic compound (2-(2-methyl-3′chloro)-anilino-nicotinic acid) on platelet function and fibrinolytic activity in vitro

AU - Widmer, K.

AU - Reed, R. C.

AU - Freireich, E. J.

PY - 1975/1

Y1 - 1975/1

N2 - The effect of a new analgetic, Clonixin, on platelet function, clot retraction and fibrinolysis was studied in vitro. In Born's photometric technique platelet aggregation was inhibited starting at a Clonixin concentration of 1×10-7M. The inhibition is strongly dose dependent and involves mostly secondary aggregation. An inhibition of clot retraction was seen only at higher concentrations (1×10-4M) of Clonixin. This is a rather striking effect for an analgeticantiphlogistic compound. Fibrinolysis was unaffected at the concentrations tested.

AB - The effect of a new analgetic, Clonixin, on platelet function, clot retraction and fibrinolysis was studied in vitro. In Born's photometric technique platelet aggregation was inhibited starting at a Clonixin concentration of 1×10-7M. The inhibition is strongly dose dependent and involves mostly secondary aggregation. An inhibition of clot retraction was seen only at higher concentrations (1×10-4M) of Clonixin. This is a rather striking effect for an analgeticantiphlogistic compound. Fibrinolysis was unaffected at the concentrations tested.

UR - http://www.scopus.com/inward/record.url?scp=0016612032&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0016612032&partnerID=8YFLogxK

U2 - 10.1016/0049-3848(75)90146-2

DO - 10.1016/0049-3848(75)90146-2

M3 - Article

C2 - 1118832

AN - SCOPUS:0016612032

SN - 0049-3848

VL - 6

SP - 9

EP - 17

JO - Thrombosis Research

JF - Thrombosis Research

IS - 1

ER -

The influence of a new analgetic-antiphlogistic compound (2-(2-methyl-3′chloro)-anilino-nicotinic acid) on platelet function and fibrinolytic activity in vitro

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this