The influence of chronic liver diseases on hepatic vasculature: A liver-on-a-chip review

Alican Özkan; Danielle Stolley; Erik N.K. Cressman; Matthew McMillin; Sharon DeMorrow; Thomas E. Yankeelov; Marissa Nichole Rylander

doi:10.3390/MI11050487

The influence of chronic liver diseases on hepatic vasculature: A liver-on-a-chip review

Alican Özkan, Danielle Stolley, Erik N.K. Cressman, Matthew McMillin, Sharon DeMorrow, Thomas E. Yankeelov, Marissa Nichole Rylander

Interventional Radiology

Research output: Contribution to journal › Review article › peer-review

20 Scopus citations

Abstract

In chronic liver diseases and hepatocellular carcinoma, the cells and extracellular matrix of the liver undergo significant alteration in response to chronic injury. Recent literature has highlighted the critical, but less studied, role of the liver vasculature in the progression of chronic liver diseases. Recent advancements in liver-on-a-chip systems has allowed in depth investigation of the role that the hepatic vasculature plays both in response to, and progression of, chronic liver disease. In this review, we first introduce the structure, gradients, mechanical properties, and cellular composition of the liver and describe how these factors influence the vasculature. We summarize state-of-the-art vascularized liver-on-a-chip platforms for investigating biological models of chronic liver disease and their influence on the liver sinusoidal endothelial cells of the hepatic vasculature. We conclude with a discussion of how future developments in the field may affect the study of chronic liver diseases, and drug development and testing.

Original language	English (US)
Article number	487
Journal	Micromachines
Volume	11
Issue number	5
DOIs	https://doi.org/10.3390/MI11050487
State	Published - May 1 2020

Keywords

Chronic liver diseases
Hepatology
Microfluidics
Organ-on-a-chip
Tissue engineering
Vascular diseases

ASJC Scopus subject areas

Control and Systems Engineering
Mechanical Engineering
Electrical and Electronic Engineering

Access to Document

10.3390/MI11050487

Cite this

@article{ecf6a163f1144bdc830228761f76271c,

title = "The influence of chronic liver diseases on hepatic vasculature: A liver-on-a-chip review",

abstract = "In chronic liver diseases and hepatocellular carcinoma, the cells and extracellular matrix of the liver undergo significant alteration in response to chronic injury. Recent literature has highlighted the critical, but less studied, role of the liver vasculature in the progression of chronic liver diseases. Recent advancements in liver-on-a-chip systems has allowed in depth investigation of the role that the hepatic vasculature plays both in response to, and progression of, chronic liver disease. In this review, we first introduce the structure, gradients, mechanical properties, and cellular composition of the liver and describe how these factors influence the vasculature. We summarize state-of-the-art vascularized liver-on-a-chip platforms for investigating biological models of chronic liver disease and their influence on the liver sinusoidal endothelial cells of the hepatic vasculature. We conclude with a discussion of how future developments in the field may affect the study of chronic liver diseases, and drug development and testing.",

keywords = "Chronic liver diseases, Hepatology, Microfluidics, Organ-on-a-chip, Tissue engineering, Vascular diseases",

author = "Alican {\"O}zkan and Danielle Stolley and Cressman, {Erik N.K.} and Matthew McMillin and Sharon DeMorrow and Yankeelov, {Thomas E.} and Rylander, {Marissa Nichole}",

note = "Funding Information: The authors acknowledge the support of the Cancer Prevention Research Institute of Texas (CPRIT) for funding part of this work through grant RR160005, National Cancer Institutes for funding through R21EB019646, R01CA186193, U24CA226110and U01CA174706, National Institute of Diabetes and Digestive and Kidney Diseases funding through awards R01DK082435 and R01DK112803 and Department of Veterans Affairs Biomedical Laboratory Research and Development Service funding through award BX003486. This work was completed with support from the Veterans Health Administration and with resources and the use of facilities at the Central Texas Veterans Health Care System, Temple, Texas. The contents do not represent the views of the U.S. Department of Veterans Affairs or the United States Government. T.E.Y. is a CPRIT scholar in cancer research. Publisher Copyright: {\textcopyright} 2020 by the authors.",

year = "2020",

month = may,

day = "1",

doi = "10.3390/MI11050487",

language = "English (US)",

volume = "11",

journal = "Micromachines",

issn = "2072-666X",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "5",

}

TY - JOUR

T1 - The influence of chronic liver diseases on hepatic vasculature

T2 - A liver-on-a-chip review

AU - Özkan, Alican

AU - Stolley, Danielle

AU - Cressman, Erik N.K.

AU - McMillin, Matthew

AU - DeMorrow, Sharon

AU - Yankeelov, Thomas E.

AU - Rylander, Marissa Nichole

N1 - Funding Information: The authors acknowledge the support of the Cancer Prevention Research Institute of Texas (CPRIT) for funding part of this work through grant RR160005, National Cancer Institutes for funding through R21EB019646, R01CA186193, U24CA226110and U01CA174706, National Institute of Diabetes and Digestive and Kidney Diseases funding through awards R01DK082435 and R01DK112803 and Department of Veterans Affairs Biomedical Laboratory Research and Development Service funding through award BX003486. This work was completed with support from the Veterans Health Administration and with resources and the use of facilities at the Central Texas Veterans Health Care System, Temple, Texas. The contents do not represent the views of the U.S. Department of Veterans Affairs or the United States Government. T.E.Y. is a CPRIT scholar in cancer research. Publisher Copyright: © 2020 by the authors.

PY - 2020/5/1

Y1 - 2020/5/1

N2 - In chronic liver diseases and hepatocellular carcinoma, the cells and extracellular matrix of the liver undergo significant alteration in response to chronic injury. Recent literature has highlighted the critical, but less studied, role of the liver vasculature in the progression of chronic liver diseases. Recent advancements in liver-on-a-chip systems has allowed in depth investigation of the role that the hepatic vasculature plays both in response to, and progression of, chronic liver disease. In this review, we first introduce the structure, gradients, mechanical properties, and cellular composition of the liver and describe how these factors influence the vasculature. We summarize state-of-the-art vascularized liver-on-a-chip platforms for investigating biological models of chronic liver disease and their influence on the liver sinusoidal endothelial cells of the hepatic vasculature. We conclude with a discussion of how future developments in the field may affect the study of chronic liver diseases, and drug development and testing.

AB - In chronic liver diseases and hepatocellular carcinoma, the cells and extracellular matrix of the liver undergo significant alteration in response to chronic injury. Recent literature has highlighted the critical, but less studied, role of the liver vasculature in the progression of chronic liver diseases. Recent advancements in liver-on-a-chip systems has allowed in depth investigation of the role that the hepatic vasculature plays both in response to, and progression of, chronic liver disease. In this review, we first introduce the structure, gradients, mechanical properties, and cellular composition of the liver and describe how these factors influence the vasculature. We summarize state-of-the-art vascularized liver-on-a-chip platforms for investigating biological models of chronic liver disease and their influence on the liver sinusoidal endothelial cells of the hepatic vasculature. We conclude with a discussion of how future developments in the field may affect the study of chronic liver diseases, and drug development and testing.

KW - Chronic liver diseases

KW - Hepatology

KW - Microfluidics

KW - Organ-on-a-chip

KW - Tissue engineering

KW - Vascular diseases

UR - http://www.scopus.com/inward/record.url?scp=85085730601&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85085730601&partnerID=8YFLogxK

U2 - 10.3390/MI11050487

DO - 10.3390/MI11050487

M3 - Review article

C2 - 32397454

AN - SCOPUS:85085730601

SN - 2072-666X

VL - 11

JO - Micromachines

JF - Micromachines

IS - 5

M1 - 487

ER -

The influence of chronic liver diseases on hepatic vasculature: A liver-on-a-chip review

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this