The influence of ras oncogene expression on radiation response in the rat-1 cell

A. S. Garden; R. E. Meyn; M. M. Weil; R. M. Lebovitz; M. W. Lieberman

doi:10.1080/09553009214552151

The influence of ras oncogene expression on radiation response in the rat-1 cell

A. S. Garden, R. E. Meyn, M. M. Weil, R. M. Lebovitz, M. W. Lieberman

Radiation Oncology

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

We evaluated the effect of H-ras oncogene expression on resistance to ionizing radiation in cultured rat fibroblasts. The Rat-1 cell line, and two Rat-1 derivatives, MR4 and MR7, carrying a Zn-regulatable metallothionein-rasT24 fusion gene were used to study the effects of the ras oncogene on radiation sensitivity. Cells were irradiated with a ¹³⁷Cs source (450 cGY/min) in the presence or absence of ZnSO₄. Multiple cell survival studies did not show an appreciable difference in sensitivity to radiation among the lines in the presence or absence of ras oncogene expression.

Original language	English (US)
Pages (from-to)	307-311
Number of pages	5
Journal	International journal of radiation biology
Volume	62
Issue number	3
DOIs	https://doi.org/10.1080/09553009214552151
State	Published - 1992

ASJC Scopus subject areas

Radiological and Ultrasound Technology
Radiology Nuclear Medicine and imaging

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10.1080/09553009214552151

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title = "The influence of ras oncogene expression on radiation response in the rat-1 cell",

abstract = "We evaluated the effect of H-ras oncogene expression on resistance to ionizing radiation in cultured rat fibroblasts. The Rat-1 cell line, and two Rat-1 derivatives, MR4 and MR7, carrying a Zn-regulatable metallothionein-rasT24 fusion gene were used to study the effects of the ras oncogene on radiation sensitivity. Cells were irradiated with a 137Cs source (450 cGY/min) in the presence or absence of ZnSO4. Multiple cell survival studies did not show an appreciable difference in sensitivity to radiation among the lines in the presence or absence of ras oncogene expression.",

author = "Garden, {A. S.} and Meyn, {R. E.} and Weil, {M. M.} and Lebovitz, {R. M.} and Lieberman, {M. W.}",

note = "Funding Information: This work was supported by a grant from the Radiological Society of North America Research and Education Fund, and NIH grant R37 CA-39392 (M .W .L .) .",

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AU - Garden, A. S.

AU - Meyn, R. E.

AU - Weil, M. M.

AU - Lebovitz, R. M.

AU - Lieberman, M. W.

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AB - We evaluated the effect of H-ras oncogene expression on resistance to ionizing radiation in cultured rat fibroblasts. The Rat-1 cell line, and two Rat-1 derivatives, MR4 and MR7, carrying a Zn-regulatable metallothionein-rasT24 fusion gene were used to study the effects of the ras oncogene on radiation sensitivity. Cells were irradiated with a 137Cs source (450 cGY/min) in the presence or absence of ZnSO4. Multiple cell survival studies did not show an appreciable difference in sensitivity to radiation among the lines in the presence or absence of ras oncogene expression.

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The influence of ras oncogene expression on radiation response in the rat-1 cell

Abstract

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