TY - GEN
T1 - The initial design and feasibility study of an affordable high-resolution 100-cm long PET
AU - Wong, Wai Hoi
AU - Zhang, Yuxuan
AU - Liu, Shitao
AU - Li, Hongdi
AU - Baghaei, Hossain
AU - Ramirez, Rocio
AU - Liu, Jiguo
PY - 2007
Y1 - 2007
N2 - This is a design and feasibility study of an affordable high-resolution 100-em long PET covering the entire body (EB-PET) for imaging head-&-torso in one fixed bed position. Our design studies show that EB-PET may image the entire body in 2-4 minutes with a low 2.5-mCi FDG dose. The high patient throughput may lower the cost of wholebody imaging and the low dose would allow more frequent cancer-management monitoring. EB-PET can capture dynamic wholebody time-activity images and arterial (cardiac) input function concurrently to yield quantitative metabolic images for the wholebody to improve diagnosis and to measure wholebody systemic side effects of therapy. Dynamic imaging using EB-PET may also unshackle wholebody PET imaging from the static FDG-type of tracers required by current PET to new classes of more dynamic tracers. The EB-PET detection system is based on the latest generation of the low-cost BGO detector prototypes developed in our laboratory which can decode 121 BGO crystals per PMT (39-mm diameter), thereby enabling this very large system to use only 1768 PMT for its 205,700 high resolution crystals (3.5 × 3.5 × 20 mm). The system resolution and NES characteristics were also calculated with Monte Carlo (MC) simulations (GATE/GEANT) for point sources, NEMA NES phantom and wholebody Turkington phantoms. Prototype detectors achieved a 15% energy resolution and clearly decoded 3.5×3.5mm detectors. With such data, MC simulations show that the central transaxial image resolution is 3.2mm (4.4mm) for 5 cross-ring coincidences (274 cross-ring coincidences), while at 10-cm transaxial radius, the image resolution is 4.2mm (5.1mm).
AB - This is a design and feasibility study of an affordable high-resolution 100-em long PET covering the entire body (EB-PET) for imaging head-&-torso in one fixed bed position. Our design studies show that EB-PET may image the entire body in 2-4 minutes with a low 2.5-mCi FDG dose. The high patient throughput may lower the cost of wholebody imaging and the low dose would allow more frequent cancer-management monitoring. EB-PET can capture dynamic wholebody time-activity images and arterial (cardiac) input function concurrently to yield quantitative metabolic images for the wholebody to improve diagnosis and to measure wholebody systemic side effects of therapy. Dynamic imaging using EB-PET may also unshackle wholebody PET imaging from the static FDG-type of tracers required by current PET to new classes of more dynamic tracers. The EB-PET detection system is based on the latest generation of the low-cost BGO detector prototypes developed in our laboratory which can decode 121 BGO crystals per PMT (39-mm diameter), thereby enabling this very large system to use only 1768 PMT for its 205,700 high resolution crystals (3.5 × 3.5 × 20 mm). The system resolution and NES characteristics were also calculated with Monte Carlo (MC) simulations (GATE/GEANT) for point sources, NEMA NES phantom and wholebody Turkington phantoms. Prototype detectors achieved a 15% energy resolution and clearly decoded 3.5×3.5mm detectors. With such data, MC simulations show that the central transaxial image resolution is 3.2mm (4.4mm) for 5 cross-ring coincidences (274 cross-ring coincidences), while at 10-cm transaxial radius, the image resolution is 4.2mm (5.1mm).
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U2 - 10.1109/NSSMIC.2007.4437029
DO - 10.1109/NSSMIC.2007.4437029
M3 - Conference contribution
AN - SCOPUS:48149101277
SN - 1424409233
SN - 9781424409235
T3 - IEEE Nuclear Science Symposium Conference Record
SP - 4117
EP - 4122
BT - 2007 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS-MIC
T2 - 2007 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS-MIC
Y2 - 27 October 2007 through 3 November 2007
ER -