TY - JOUR
T1 - The INK4A/ARF locus and its two gene products
AU - Sharpless, Norman E.
AU - Depinho, Ronald A.
N1 - Funding Information:
We would like to thank M Serrano and C Sherr for communicating unpublished data. We would like to thank L Chin, S Grossman, W Kaelin, B Rollins, and N Schreiber-Agus for critical reading of the manuscript. N Sharpless is a Howard Hughes Physician Postdoctoral Fellow. R DePinho is an American Cancer Society Research Professor and is supported by National Institutes of Health grants RO1 HD28317 and RO1 EY11267.
PY - 1999/2/1
Y1 - 1999/2/1
N2 - The INK4A/ARF locus on chromosome 9 is one of the sites mutated most frequently in human cancer. Two genes comprising overlapping reading frames encoding p16(INK4a) and p19(ARF) have been discovered at this locus and, remarkably, both play an important role in regulating cell growth, survival and senescence.
AB - The INK4A/ARF locus on chromosome 9 is one of the sites mutated most frequently in human cancer. Two genes comprising overlapping reading frames encoding p16(INK4a) and p19(ARF) have been discovered at this locus and, remarkably, both play an important role in regulating cell growth, survival and senescence.
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U2 - 10.1016/S0959-437X(99)80004-5
DO - 10.1016/S0959-437X(99)80004-5
M3 - Article
C2 - 10072356
AN - SCOPUS:0033037541
SN - 0959-437X
VL - 9
SP - 22
EP - 30
JO - Current Opinion in Genetics and Development
JF - Current Opinion in Genetics and Development
IS - 1
ER -