The joint effect of aging and HIV infection on microstructure of white matter bundles

Taylor Kuhn; Yan Jin; Chao Huang; Yeun Kim; Talia M. Nir; Joseph M. Gullett; Jacob D. Jones; Phillip Sayegh; Caroline Chung; Bianca H. Dang; Elyse J. Singer; David W. Shattuck; Neda Jahanshad; Susan Y. Bookheimer; Charles H. Hinkin; Hongtu Zhu; Paul M. Thompson; April D. Thames

doi:10.1002/hbm.24708

The joint effect of aging and HIV infection on microstructure of white matter bundles

Taylor Kuhn, Yan Jin, Chao Huang, Yeun Kim, Talia M. Nir, Joseph M. Gullett, Jacob D. Jones, Phillip Sayegh, Caroline Chung, Bianca H. Dang, Elyse J. Singer, David W. Shattuck, Neda Jahanshad, Susan Y. Bookheimer, Charles H. Hinkin, Hongtu Zhu, Paul M. Thompson, April D. Thames

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Recent evidence suggests the aging process is accelerated by HIV. Degradation of white matter (WM) has been independently associated with HIV and healthy aging. Thus, WM may be vulnerable to joint effects of HIV and aging. Diffusion-weighted imaging (DWI) was conducted with HIV-seropositive (n = 72) and HIV-seronegative (n = 34) adults. DWI data underwent tractography, which was parcellated into 18 WM tracts of interest (TOIs). Functional Analysis of Diffusion Tensor Tract Statistics (FADTTS) regression was conducted assessing the joint effect of advanced age and HIV on fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD) along TOI fibers. In addition to main effects of age and HIV on WM microstructure, the interactive effect of age and HIV was significantly related to lower FA and higher MD, AD, and RD across all TOIs. The location of findings was consistent with the clinical presentation of HIV-associated neurocognitive disorders. While older age is related to poorer WM microstructure, its detrimental effect on WM is stronger among HIV+ relative to HIV− individuals. Loss of WM integrity in the context of advancing age may place HIV+ individuals at increased risk for brain and cognitive compromise.

Original language	English (US)
Pages (from-to)	4370-4380
Number of pages	11
Journal	Human Brain Mapping
Volume	40
Issue number	15
DOIs	https://doi.org/10.1002/hbm.24708
State	Published - Oct 15 2019

Keywords

DTI
HIV
aging
tractography
white matter

ASJC Scopus subject areas

Anatomy
Radiological and Ultrasound Technology
Radiology Nuclear Medicine and imaging
Neurology
Clinical Neurology

MD Anderson CCSG core facilities

Biostatistics Resource Group

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10.1002/hbm.24708

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Kuhn, T., Jin, Y., Huang, C., Kim, Y., Nir, T. M., Gullett, J. M., Jones, J. D., Sayegh, P., Chung, C., Dang, B. H., Singer, E. J., Shattuck, D. W., Jahanshad, N., Bookheimer, S. Y., Hinkin, C. H., Zhu, H., Thompson, P. M., & Thames, A. D. (2019). The joint effect of aging and HIV infection on microstructure of white matter bundles. Human Brain Mapping, 40(15), 4370-4380. https://doi.org/10.1002/hbm.24708

Kuhn, T, Jin, Y, Huang, C, Kim, Y, Nir, TM, Gullett, JM, Jones, JD, Sayegh, P, Chung, C, Dang, BH, Singer, EJ, Shattuck, DW, Jahanshad, N, Bookheimer, SY, Hinkin, CH, Zhu, H, Thompson, PM & Thames, AD 2019, 'The joint effect of aging and HIV infection on microstructure of white matter bundles', Human Brain Mapping, vol. 40, no. 15, pp. 4370-4380. https://doi.org/10.1002/hbm.24708

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abstract = "Recent evidence suggests the aging process is accelerated by HIV. Degradation of white matter (WM) has been independently associated with HIV and healthy aging. Thus, WM may be vulnerable to joint effects of HIV and aging. Diffusion-weighted imaging (DWI) was conducted with HIV-seropositive (n = 72) and HIV-seronegative (n = 34) adults. DWI data underwent tractography, which was parcellated into 18 WM tracts of interest (TOIs). Functional Analysis of Diffusion Tensor Tract Statistics (FADTTS) regression was conducted assessing the joint effect of advanced age and HIV on fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD) along TOI fibers. In addition to main effects of age and HIV on WM microstructure, the interactive effect of age and HIV was significantly related to lower FA and higher MD, AD, and RD across all TOIs. The location of findings was consistent with the clinical presentation of HIV-associated neurocognitive disorders. While older age is related to poorer WM microstructure, its detrimental effect on WM is stronger among HIV+ relative to HIV− individuals. Loss of WM integrity in the context of advancing age may place HIV+ individuals at increased risk for brain and cognitive compromise.",

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AU - Jin, Yan

AU - Huang, Chao

AU - Kim, Yeun

AU - Nir, Talia M.

AU - Gullett, Joseph M.

AU - Jones, Jacob D.

AU - Sayegh, Phillip

AU - Chung, Caroline

AU - Dang, Bianca H.

AU - Singer, Elyse J.

AU - Shattuck, David W.

AU - Jahanshad, Neda

AU - Bookheimer, Susan Y.

AU - Hinkin, Charles H.

AU - Zhu, Hongtu

AU - Thompson, Paul M.

AU - Thames, April D.

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AB - Recent evidence suggests the aging process is accelerated by HIV. Degradation of white matter (WM) has been independently associated with HIV and healthy aging. Thus, WM may be vulnerable to joint effects of HIV and aging. Diffusion-weighted imaging (DWI) was conducted with HIV-seropositive (n = 72) and HIV-seronegative (n = 34) adults. DWI data underwent tractography, which was parcellated into 18 WM tracts of interest (TOIs). Functional Analysis of Diffusion Tensor Tract Statistics (FADTTS) regression was conducted assessing the joint effect of advanced age and HIV on fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD) along TOI fibers. In addition to main effects of age and HIV on WM microstructure, the interactive effect of age and HIV was significantly related to lower FA and higher MD, AD, and RD across all TOIs. The location of findings was consistent with the clinical presentation of HIV-associated neurocognitive disorders. While older age is related to poorer WM microstructure, its detrimental effect on WM is stronger among HIV+ relative to HIV− individuals. Loss of WM integrity in the context of advancing age may place HIV+ individuals at increased risk for brain and cognitive compromise.

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The joint effect of aging and HIV infection on microstructure of white matter bundles

Abstract

Keywords

ASJC Scopus subject areas

MD Anderson CCSG core facilities

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