The lens capsule

Brian P. Danysh; Melinda K. Duncan

doi:10.1016/j.exer.2008.08.002

The lens capsule

Brian P. Danysh, Melinda K. Duncan

Endocrine Neoplasia & HD

Research output: Contribution to journal › Review article › peer-review

190 Scopus citations

Abstract

The lens capsule is a modified basement membrane that completely surrounds the ocular lens. It is known that this extracellular matrix is important for both the structure and biomechanics of the lens in addition to providing informational cues to maintain lens cell phenotype. This review covers the development and structure of the lens capsule, lens diseases associated with mutations in extracellular matrix genes and the role of the capsule in lens function including those proposed for visual accommodation, selective permeability to infectious agents, and cell signaling.

Original language	English (US)
Pages (from-to)	151-164
Number of pages	14
Journal	Experimental Eye Research
Volume	88
Issue number	2
DOIs	https://doi.org/10.1016/j.exer.2008.08.002
State	Published - Feb 2 2009

Keywords

accommodation
basement membrane
lens capsule

ASJC Scopus subject areas

Ophthalmology
Sensory Systems
Cellular and Molecular Neuroscience

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10.1016/j.exer.2008.08.002

Cite this

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title = "The lens capsule",

abstract = "The lens capsule is a modified basement membrane that completely surrounds the ocular lens. It is known that this extracellular matrix is important for both the structure and biomechanics of the lens in addition to providing informational cues to maintain lens cell phenotype. This review covers the development and structure of the lens capsule, lens diseases associated with mutations in extracellular matrix genes and the role of the capsule in lens function including those proposed for visual accommodation, selective permeability to infectious agents, and cell signaling.",

keywords = "accommodation, basement membrane, lens capsule",

author = "Danysh, {Brian P.} and Duncan, {Melinda K.}",

note = "Funding Information: The preparation of this review was supported by National Eye Institute grant EY015279. We are grateful to Dr. John Novotny for critical reading of the manuscript.",

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AU - Danysh, Brian P.

AU - Duncan, Melinda K.

N1 - Funding Information: The preparation of this review was supported by National Eye Institute grant EY015279. We are grateful to Dr. John Novotny for critical reading of the manuscript.

PY - 2009/2/2

Y1 - 2009/2/2

N2 - The lens capsule is a modified basement membrane that completely surrounds the ocular lens. It is known that this extracellular matrix is important for both the structure and biomechanics of the lens in addition to providing informational cues to maintain lens cell phenotype. This review covers the development and structure of the lens capsule, lens diseases associated with mutations in extracellular matrix genes and the role of the capsule in lens function including those proposed for visual accommodation, selective permeability to infectious agents, and cell signaling.

AB - The lens capsule is a modified basement membrane that completely surrounds the ocular lens. It is known that this extracellular matrix is important for both the structure and biomechanics of the lens in addition to providing informational cues to maintain lens cell phenotype. This review covers the development and structure of the lens capsule, lens diseases associated with mutations in extracellular matrix genes and the role of the capsule in lens function including those proposed for visual accommodation, selective permeability to infectious agents, and cell signaling.

KW - accommodation

KW - basement membrane

KW - lens capsule

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JO - Experimental Eye Research

JF - Experimental Eye Research

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ER -

The lens capsule

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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