TY - JOUR
T1 - The linkage of chromatin remodeling to genome maintenance
T2 - Contribution from a human disease gene BRIT1/MCPH1
AU - Peng, Guang
AU - Lin, Shiaw Yih
N1 - Funding Information:
G.P. is supported by a postdoctoral fellowship from Susan G. Komen for the Cure.
Funding Information:
This work was supported by grants from the NCI (R01CA112291) and American Cancer Society Research Scholar Award to S.Y.L.
PY - 2009/10/1
Y1 - 2009/10/1
N2 - Genomic DNA is packed into a highly condensed chromatin structure, which acts as natural barrier preventing accessibility of DNA. In various processes to maintain genomic integrity such as DNA replication, DNA repair, telomere regulation, proteins need to overcome the barrier of condensed chromatin to gain access to DNA. ATPdependent chromatin remodeling is one of the fundamental mechanisms used by cells to relax chromatin. However, the chromatin remodeling complex does not contain intrinsic specificity for particular nuclear process, and the mechanism mediating its recruitment to DNA lesions remains to be an outstanding question. To address this question, in this review, we will discuss our current findings and future perspectives about how BRIT1/ MCPH1, a human disease gene, speci-fies the function of chromatin remodelers and links chromatin remodeling to genome maintenance.
AB - Genomic DNA is packed into a highly condensed chromatin structure, which acts as natural barrier preventing accessibility of DNA. In various processes to maintain genomic integrity such as DNA replication, DNA repair, telomere regulation, proteins need to overcome the barrier of condensed chromatin to gain access to DNA. ATPdependent chromatin remodeling is one of the fundamental mechanisms used by cells to relax chromatin. However, the chromatin remodeling complex does not contain intrinsic specificity for particular nuclear process, and the mechanism mediating its recruitment to DNA lesions remains to be an outstanding question. To address this question, in this review, we will discuss our current findings and future perspectives about how BRIT1/ MCPH1, a human disease gene, speci-fies the function of chromatin remodelers and links chromatin remodeling to genome maintenance.
KW - ATP-dependent chromatin remodeling
KW - BRIT1/MCPH1
KW - DNA damage response
KW - Genome integrity
KW - SWI/SNF
UR - http://www.scopus.com/inward/record.url?scp=73449098583&partnerID=8YFLogxK
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U2 - 10.4161/epi.4.7.10032
DO - 10.4161/epi.4.7.10032
M3 - Review article
C2 - 19829069
AN - SCOPUS:73449098583
SN - 1559-2294
VL - 4
SP - 457
EP - 461
JO - Epigenetics
JF - Epigenetics
IS - 7
ER -