Abstract
The variability of the MHC restricted receptor on murine T cells was examined by comparing tryptic peptide fingerprints of the receptor isolated four three T cell hybridomas and a T cell tumor. Both variable and constant peptides were seen. Constant peptides were most apparent when comparing receptors from the same mouse strain. Peptide fingerprints of receptors from two independent T cell hybridomas with the same idiotype and specificity were identical. We also describe a molecule detected on the surface of a human T cell leukemia whose properties were identical to those reported for the MHC receptor on normal human T cells. The molecule was a dimer of 85,000-90,000 MW containing a 46,000 MW acidic α-chain and an unrelated 40,000 MW neutral β-chain.
Original language | English (US) |
---|---|
Pages (from-to) | 295-302 |
Number of pages | 8 |
Journal | Cell |
Volume | 35 |
Issue number | 1 |
DOIs | |
State | Published - Nov 1983 |
Externally published | Yes |
ASJC Scopus subject areas
- General Biochemistry, Genetics and Molecular Biology