@article{e3d05e99f83e4df79a6def9e4097a7c5,
title = "The Many Faces of Long Noncoding RNAs in Cancer",
abstract = "Significance: The emerging connections between an increasing number of long noncoding RNAs (lncRNAs) and oncogenic hallmarks provide a new twist to tumor complexity. Recent Advances: In the present review, we highlight specific lncRNAs that have been studied in relation to tumorigenesis, either as participants in the neoplastic process or as markers of pathway activity or drug response. These transcripts are typically deregulated by oncogenic or tumor-suppressing signals or respond to microenvironmental conditions such as hypoxia. Critical Issues: Among these transcripts are lncRNAs sufficiently divergent between mouse and human genomes that may contribute to biological differences between species. Future Directions: From a translational standpoint, knowledge about primate-specific lncRNAs may help explain the reason behind the failure to reproduce the results from mouse cancer models in human cell-based systems. Antioxid. Redox Signal. 29, 922-935.",
keywords = "cancer, hypoxia, metabolism, microenvironment, non-coding RNA",
author = "Xue Wu and Tudoran, {Oana M.} and Calin, {George A.} and Mircea Ivan",
note = "Funding Information: Work in Dr. Ivan{\textquoteright}s laboratory is supported by a National Institutes of Health (NIH/NCI) grant R01CA155332; Dr. Calin{\textquoteright}s laboratory is supported by National Institutes of Health (NIH/NCATS) grant UH3TR00943-01 through the NIH Common Fund, Office of Strategic Coordination (OSC); the NIH/ NCI grant 1 R01 CA182905-01; U54 grant—UPR/MDACC Partnership for Excellence in Cancer Research 2016 Pilot Project; CLL Moonshot Flagship project; and the Estate of C.G. Johnson, Jr.; and Dr. Tudoran{\textquoteright}s work is supported by the Romanian National Grant Program PN-II-RU-TE-2014-4-1984. Funding Information: Work in Dr. Ivan's laboratory is supported by a National Institutes of Health (NIH/NCI) grant R01CA155332; Dr. Calin's laboratory is supported by National Institutes of Health (NIH/NCATS) grant UH3TR00943-01 through the NIH Common Fund, Office of Strategic Coordination (OSC); the NIH/ NCI grant 1 R01 CA182905-01; U54 grant - UPR/MDACC Partnership for Excellence in Cancer Research 2016 Pilot Project; CLLMoonshot Flagship project; and the Estate of C.G. Johnson, Jr.; and Dr. Tudoran's work is supported by the Romanian National Grant Program PN-II-RU-TE-2014-4-1984. Publisher Copyright: {\textcopyright} Xue Wu et al. 2017.",
year = "2018",
month = sep,
day = "20",
doi = "10.1089/ars.2017.7293",
language = "English (US)",
volume = "29",
pages = "922--935",
journal = "Antioxidants and Redox Signaling",
issn = "1523-0864",
publisher = "Mary Ann Liebert Inc.",
number = "9",
}