The metabolic fate of acetate in cancer

Zachary T. Schug; Johan Vande Voorde; Eyal Gottlieb

doi:10.1038/nrc.2016.87

The metabolic fate of acetate in cancer

Zachary T. Schug, Johan Vande Voorde, Eyal Gottlieb

Research output: Contribution to journal › Review article › peer-review

211 Scopus citations

Abstract

Recent high-profile reports have reignited an interest in acetate metabolism in cancer. Acetyl-CoA synthetases that catalyse the conversion of acetate to acetyl-CoA have now been implicated in the growth of hepatocellular carcinoma, glioblastoma, breast cancer and prostate cancer. In this Review, we discuss how acetate functions as a nutritional source for tumours and as a regulator of cancer cell stress, and how preventing its (re)capture by cancer cells may provide an opportunity for therapeutic intervention.

Original language	English (US)
Pages (from-to)	708-717
Number of pages	10
Journal	Nature Reviews Cancer
Volume	16
Issue number	11
DOIs	https://doi.org/10.1038/nrc.2016.87
State	Published - Oct 24 2016
Externally published	Yes

ASJC Scopus subject areas

Oncology
Cancer Research

Access to Document

10.1038/nrc.2016.87

Cite this

@article{1883aa6cd746448d92738ab4d3bc79e1,

title = "The metabolic fate of acetate in cancer",

abstract = "Recent high-profile reports have reignited an interest in acetate metabolism in cancer. Acetyl-CoA synthetases that catalyse the conversion of acetate to acetyl-CoA have now been implicated in the growth of hepatocellular carcinoma, glioblastoma, breast cancer and prostate cancer. In this Review, we discuss how acetate functions as a nutritional source for tumours and as a regulator of cancer cell stress, and how preventing its (re)capture by cancer cells may provide an opportunity for therapeutic intervention.",

author = "Schug, {Zachary T.} and {Vande Voorde}, Johan and Eyal Gottlieb",

note = "Publisher Copyright: {\textcopyright} 2016 Macmillan Publishers Limited, part of Springer Nature.",

year = "2016",

month = oct,

day = "24",

doi = "10.1038/nrc.2016.87",

language = "English (US)",

volume = "16",

pages = "708--717",

journal = "Nature Reviews Cancer",

issn = "1474-175X",

publisher = "Nature Publishing Group",

number = "11",

}

TY - JOUR

T1 - The metabolic fate of acetate in cancer

AU - Schug, Zachary T.

AU - Vande Voorde, Johan

AU - Gottlieb, Eyal

PY - 2016/10/24

Y1 - 2016/10/24

N2 - Recent high-profile reports have reignited an interest in acetate metabolism in cancer. Acetyl-CoA synthetases that catalyse the conversion of acetate to acetyl-CoA have now been implicated in the growth of hepatocellular carcinoma, glioblastoma, breast cancer and prostate cancer. In this Review, we discuss how acetate functions as a nutritional source for tumours and as a regulator of cancer cell stress, and how preventing its (re)capture by cancer cells may provide an opportunity for therapeutic intervention.

AB - Recent high-profile reports have reignited an interest in acetate metabolism in cancer. Acetyl-CoA synthetases that catalyse the conversion of acetate to acetyl-CoA have now been implicated in the growth of hepatocellular carcinoma, glioblastoma, breast cancer and prostate cancer. In this Review, we discuss how acetate functions as a nutritional source for tumours and as a regulator of cancer cell stress, and how preventing its (re)capture by cancer cells may provide an opportunity for therapeutic intervention.

UR - http://www.scopus.com/inward/record.url?scp=84983437346&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84983437346&partnerID=8YFLogxK

U2 - 10.1038/nrc.2016.87

DO - 10.1038/nrc.2016.87

M3 - Review article

C2 - 27562461

AN - SCOPUS:84983437346

SN - 1474-175X

VL - 16

SP - 708

EP - 717

JO - Nature Reviews Cancer

JF - Nature Reviews Cancer

IS - 11

ER -

The metabolic fate of acetate in cancer

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this