The metabolic syndrome and the heart - A considered opinion

J. G. Leichman; V. R. Lavis; D. Aguilar; C. R. Wilson; H. Taegtmeyer

doi:10.1007/s00392-006-1119-7

The metabolic syndrome and the heart - A considered opinion

J. G. Leichman, V. R. Lavis, D. Aguilar, C. R. Wilson, H. Taegtmeyer

Endocrine Neoplasia & HD

Research output: Contribution to journal › Review article › peer-review

17 Scopus citations

Abstract

The metabolic syndrome (MS) is a multifactorial, heterogeneous group of risk factors for the development of cardiovascular disease. Here we review the evidence in support of the hypothesis that metabolic dysregulation of the body as a whole leads to contractile dysfunction of the heart due to an imbalance of substrate uptake (increased) and substrate oxidation (decreased). The consequences of this imbalance were already recognized 150 years ago by Virchow when he described "fatty atrophy" of the heart as a "true metamorphosis of the heart muscle cell.".

Original language	English (US)
Pages (from-to)	I/134-I/141
Journal	Clinical Research in Cardiology
Volume	95
Issue number	1 SUPPL.
DOIs	https://doi.org/10.1007/s00392-006-1119-7
State	Published - Jan 2006

Keywords

Diabetes
Fatty acids
Heart failure
Metabolic syndrome
Obesity

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1007/s00392-006-1119-7

Cite this

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AU - Aguilar, D.

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N2 - The metabolic syndrome (MS) is a multifactorial, heterogeneous group of risk factors for the development of cardiovascular disease. Here we review the evidence in support of the hypothesis that metabolic dysregulation of the body as a whole leads to contractile dysfunction of the heart due to an imbalance of substrate uptake (increased) and substrate oxidation (decreased). The consequences of this imbalance were already recognized 150 years ago by Virchow when he described "fatty atrophy" of the heart as a "true metamorphosis of the heart muscle cell.".

AB - The metabolic syndrome (MS) is a multifactorial, heterogeneous group of risk factors for the development of cardiovascular disease. Here we review the evidence in support of the hypothesis that metabolic dysregulation of the body as a whole leads to contractile dysfunction of the heart due to an imbalance of substrate uptake (increased) and substrate oxidation (decreased). The consequences of this imbalance were already recognized 150 years ago by Virchow when he described "fatty atrophy" of the heart as a "true metamorphosis of the heart muscle cell.".

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KW - Fatty acids

KW - Heart failure

KW - Metabolic syndrome

KW - Obesity

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The metabolic syndrome and the heart - A considered opinion

Abstract

Keywords

ASJC Scopus subject areas

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