The molecular pathology of sarcomas

Martin Powers; Wei Zhang; Dolores Lopez-Terrada; A. Czerniak; Alexander J. Lazar

doi:10.3233/978-1-61499-024-6-475

The molecular pathology of sarcomas

Martin Powers, Wei Zhang, Dolores Lopez-Terrada, A. Czerniak, Alexander J. Lazar

Research output: Chapter in Book/Report/Conference proceeding › Chapter

1 Scopus citations

Abstract

Sarcomas are rare malignancies of mesenchymal lineage with more than 100 specific types and manybenign potential mimics. In situ and precursor lesions are generally not described and thus much of molecular pathology in this field concentrates on molecular diagnosis, prognosis and determination of therapeutic targets. This chapter discusses the applications of molecular methodologies that provide insight into pathogenesis of sarcoma, and of molecular methods which are currently applied to, or will likely soon influence, the clinical management of this complex array of tumors.

Original language	English (US)
Title of host publication	Translational Pathology of Early Cancer
Publisher	IOS Press
Pages	475-491
Number of pages	17
ISBN (Print)	9781614990239
DOIs	https://doi.org/10.3233/978-1-61499-024-6-475
State	Published - Mar 2012

Keywords

Beta-catenin (CTNNB1)
Desmoid fibromatosis
EWSR1
Ewing sarcoma
Fluoresence in-situ hybridization (FISH)
Fusion transcript
Gastrointestinal stromal tumor (GIST)
Genomic profiling
KIT
Karyotype
Leiomyosarcoma
Malignant peripheral nerve sheath tumor (MPNST)
Molecular diagnostics
PDGRA
Pigmented villonodular synovitis
Reverse transcriptase-polymerase chain reaction (RT-PCR)
Sarcoma
Translocation

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology
General Medicine

Access to Document

10.3233/978-1-61499-024-6-475

Cite this

@inbook{9278a3caf6c1408a8d9012f70b1f3457,

title = "The molecular pathology of sarcomas",

abstract = "Sarcomas are rare malignancies of mesenchymal lineage with more than 100 specific types and manybenign potential mimics. In situ and precursor lesions are generally not described and thus much of molecular pathology in this field concentrates on molecular diagnosis, prognosis and determination of therapeutic targets. This chapter discusses the applications of molecular methodologies that provide insight into pathogenesis of sarcoma, and of molecular methods which are currently applied to, or will likely soon influence, the clinical management of this complex array of tumors.",

keywords = "Beta-catenin (CTNNB1), Desmoid fibromatosis, EWSR1, Ewing sarcoma, Fluoresence in-situ hybridization (FISH), Fusion transcript, Gastrointestinal stromal tumor (GIST), Genomic profiling, KIT, Karyotype, Leiomyosarcoma, Malignant peripheral nerve sheath tumor (MPNST), Molecular diagnostics, PDGRA, Pigmented villonodular synovitis, Reverse transcriptase-polymerase chain reaction (RT-PCR), Sarcoma, Translocation",

author = "Martin Powers and Wei Zhang and Dolores Lopez-Terrada and A. Czerniak and Lazar, {Alexander J.}",

year = "2012",

month = mar,

doi = "10.3233/978-1-61499-024-6-475",

language = "English (US)",

isbn = "9781614990239",

pages = "475--491",

booktitle = "Translational Pathology of Early Cancer",

publisher = "IOS Press",

address = "Netherlands",

}

TY - CHAP

T1 - The molecular pathology of sarcomas

AU - Powers, Martin

AU - Zhang, Wei

AU - Lopez-Terrada, Dolores

AU - Czerniak, A.

AU - Lazar, Alexander J.

PY - 2012/3

Y1 - 2012/3

N2 - Sarcomas are rare malignancies of mesenchymal lineage with more than 100 specific types and manybenign potential mimics. In situ and precursor lesions are generally not described and thus much of molecular pathology in this field concentrates on molecular diagnosis, prognosis and determination of therapeutic targets. This chapter discusses the applications of molecular methodologies that provide insight into pathogenesis of sarcoma, and of molecular methods which are currently applied to, or will likely soon influence, the clinical management of this complex array of tumors.

AB - Sarcomas are rare malignancies of mesenchymal lineage with more than 100 specific types and manybenign potential mimics. In situ and precursor lesions are generally not described and thus much of molecular pathology in this field concentrates on molecular diagnosis, prognosis and determination of therapeutic targets. This chapter discusses the applications of molecular methodologies that provide insight into pathogenesis of sarcoma, and of molecular methods which are currently applied to, or will likely soon influence, the clinical management of this complex array of tumors.

KW - Beta-catenin (CTNNB1)

KW - Desmoid fibromatosis

KW - EWSR1

KW - Ewing sarcoma

KW - Fluoresence in-situ hybridization (FISH)

KW - Fusion transcript

KW - Gastrointestinal stromal tumor (GIST)

KW - Genomic profiling

KW - KIT

KW - Karyotype

KW - Leiomyosarcoma

KW - Malignant peripheral nerve sheath tumor (MPNST)

KW - Molecular diagnostics

KW - PDGRA

KW - Pigmented villonodular synovitis

KW - Reverse transcriptase-polymerase chain reaction (RT-PCR)

KW - Sarcoma

KW - Translocation

UR - http://www.scopus.com/inward/record.url?scp=84880188552&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84880188552&partnerID=8YFLogxK

U2 - 10.3233/978-1-61499-024-6-475

DO - 10.3233/978-1-61499-024-6-475

M3 - Chapter

AN - SCOPUS:84880188552

SN - 9781614990239

SP - 475

EP - 491

BT - Translational Pathology of Early Cancer

PB - IOS Press

ER -

The molecular pathology of sarcomas

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this