The molecular pathology of sarcomas

Martin Powers; Wei Zhang; Dolores Lopez-Terrada; Bogdan A. Czerniak; Alexander J. Lazar

doi:10.3233/CBM-2011-0170

The molecular pathology of sarcomas

Martin Powers, Wei Zhang, Dolores Lopez-Terrada, Bogdan A. Czerniak, Alexander J. Lazar

Pathology

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Sarcomas are rare malignancies of mesenchymal lineage with more than 100 specific types and many benign potential mimics. In situ and precursor lesions are generally not described and thus much of molecular pathology in this field concentrates on molecular diagnosis, prognosis and determination of therapeutic targets. This chapter discusses the applications of molecular methodologies that provide insight into pathogenesis of sarcoma, and of molecular methods which are currently applied to, or will likely soon influence, the clinical management of this complex array of tumors.

Original language	English (US)
Pages (from-to)	475-491
Number of pages	17
Journal	Cancer Biomarkers
Volume	9
Issue number	1-6
DOIs	https://doi.org/10.3233/CBM-2011-0170
State	Published - 2011

Keywords

EWSR1
Ewing sarcoma
KIT
PDGRA
Sarcoma
beta-catenin (CTNNB1)
desmoid fibromatosis
fluoresence in-situ hybridization (FISH)
fusion transcript
gastrointestinal stromal tumor (GIST)
genomic profiling
karyotype
leiomyosarcoma
malignant peripheral nerve sheath tumor (MPNST)
molecular diagnostics
pigmented villonodular synovitis
reverse transcriptase-polymerase chain reaction (RT-PCR)
translocation

ASJC Scopus subject areas

Oncology
Genetics
Cancer Research

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title = "The molecular pathology of sarcomas",

abstract = "Sarcomas are rare malignancies of mesenchymal lineage with more than 100 specific types and many benign potential mimics. In situ and precursor lesions are generally not described and thus much of molecular pathology in this field concentrates on molecular diagnosis, prognosis and determination of therapeutic targets. This chapter discusses the applications of molecular methodologies that provide insight into pathogenesis of sarcoma, and of molecular methods which are currently applied to, or will likely soon influence, the clinical management of this complex array of tumors.",

keywords = "EWSR1, Ewing sarcoma, KIT, PDGRA, Sarcoma, beta-catenin (CTNNB1), desmoid fibromatosis, fluoresence in-situ hybridization (FISH), fusion transcript, gastrointestinal stromal tumor (GIST), genomic profiling, karyotype, leiomyosarcoma, malignant peripheral nerve sheath tumor (MPNST), molecular diagnostics, pigmented villonodular synovitis, reverse transcriptase-polymerase chain reaction (RT-PCR), translocation",

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AU - Powers, Martin

AU - Zhang, Wei

AU - Lopez-Terrada, Dolores

AU - Czerniak, Bogdan A.

AU - Lazar, Alexander J.

PY - 2011

Y1 - 2011

N2 - Sarcomas are rare malignancies of mesenchymal lineage with more than 100 specific types and many benign potential mimics. In situ and precursor lesions are generally not described and thus much of molecular pathology in this field concentrates on molecular diagnosis, prognosis and determination of therapeutic targets. This chapter discusses the applications of molecular methodologies that provide insight into pathogenesis of sarcoma, and of molecular methods which are currently applied to, or will likely soon influence, the clinical management of this complex array of tumors.

AB - Sarcomas are rare malignancies of mesenchymal lineage with more than 100 specific types and many benign potential mimics. In situ and precursor lesions are generally not described and thus much of molecular pathology in this field concentrates on molecular diagnosis, prognosis and determination of therapeutic targets. This chapter discusses the applications of molecular methodologies that provide insight into pathogenesis of sarcoma, and of molecular methods which are currently applied to, or will likely soon influence, the clinical management of this complex array of tumors.

KW - EWSR1

KW - Ewing sarcoma

KW - KIT

KW - PDGRA

KW - Sarcoma

KW - beta-catenin (CTNNB1)

KW - desmoid fibromatosis

KW - fluoresence in-situ hybridization (FISH)

KW - fusion transcript

KW - gastrointestinal stromal tumor (GIST)

KW - genomic profiling

KW - karyotype

KW - leiomyosarcoma

KW - malignant peripheral nerve sheath tumor (MPNST)

KW - molecular diagnostics

KW - pigmented villonodular synovitis

KW - reverse transcriptase-polymerase chain reaction (RT-PCR)

KW - translocation

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SN - 1574-0153

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EP - 491

JO - Cancer Biomarkers

JF - Cancer Biomarkers

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ER -

The molecular pathology of sarcomas

Abstract

Keywords

ASJC Scopus subject areas

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