TY - JOUR
T1 - The multi-societal European consensus on the terminology, diagnosis and management of patients with synchronous colorectal cancer and liver metastases
T2 - an E-AHPBA consensus in partnership with ESSO, ESCP, ESGAR, and CIRSE
AU - Joint E-AHPBA/ESSO/ESCP/ESGAR/CIRSE 2022 Consensus on colorectal cancer with synchronous liver metastases
AU - Siriwardena, Ajith K.
AU - Serrablo, Alejandro
AU - Fretland, Åsmund A.
AU - Wigmore, Stephen J.
AU - Ramia-Angel, Jose M.
AU - Malik, Hassan Z.
AU - Stättner, Stefan
AU - Søreide, Kjetil
AU - Zmora, Oded
AU - Meijerink, Martijn
AU - Kartalis, Nikolaos
AU - Lesurtel, Mickaël
AU - Verhoef, Cornelis
AU - Balakrishnan, Anita
AU - Gruenberger, Thomas
AU - Jonas, Eduard
AU - Devar, John
AU - Jamdar, Saurabh
AU - Jones, Robert
AU - Hilal, Mohammad A.
AU - Andersson, Bodil
AU - Boudjema, Karim
AU - Mullamitha, Saifee
AU - Stassen, Laurents
AU - Dasari, Bobby V.M.
AU - Frampton, Adam E.
AU - Aldrighetti, Luca
AU - Pellino, Gianluca
AU - Buchwald, Pamela
AU - Gürses, Bengi
AU - Wasserberg, Nir
AU - Gruenberger, Birgit
AU - Spiers, Harry V.M.
AU - Jarnagin, William
AU - Vauthey, Jean Nicholas
AU - Kokudo, Norihiro
AU - Tejpar, Sabine
AU - Valdivieso, Andres
AU - Adam, René
AU - Hauke Lang, Lang
AU - Smith, Martin
AU - deOliveira, Michelle L.
AU - Adair, Anya
AU - Gilg, Stefan
AU - Swijnenburg, Rutger Jan
AU - Jaekers, Joris
AU - Jegatheeswaran, Santhalingam
AU - Buis, Carlijn
AU - Parks, Rowan
AU - Bockhorn, Maximilian
N1 - Publisher Copyright:
© 2023 The Author(s)
PY - 2023/9
Y1 - 2023/9
N2 - Background: Contemporary management of patients with synchronous colorectal cancer and liver metastases is complex. The aim of this project was to provide a practical framework for care of patients with synchronous colorectal cancer and liver metastases with a focus on terminology, diagnosis and management. Methods: This project was a multi-organisational, multidisciplinary consensus. The consensus group produced statements which focused on terminology, diagnosis and management. Statements were refined during an online Delphi process and those with 70% agreement or above were reviewed at a final meeting. Iterations of the report were shared by electronic mail to arrive at a final agreed document comprising twelve key statements. Results: Synchronous liver metastases are those detected at the time of presentation of the primary tumour. The term “early metachronous metastases” applies to those absent at presentation but detected within 12 months of diagnosis of the primary tumour with “late metachronous metastases” applied to those detected after 12 months. Disappearing metastases applies to lesions which are no longer detectable on MR scan after systemic chemotherapy. Guidance was provided on the recommended composition of tumour boards and clinical assessment in emergency and elective settings. The consensus focused on treatment pathways including systemic chemotherapy, synchronous surgery and the staged approach with either colorectal or liver-directed surgery as first step. Management of pulmonary metastases and the role of minimally invasive surgery was discussed. Conclusions: The recommendations of this contemporary consensus provide information of practical value to clinicians managing patients with synchronous colorectal cancer and liver metastases.
AB - Background: Contemporary management of patients with synchronous colorectal cancer and liver metastases is complex. The aim of this project was to provide a practical framework for care of patients with synchronous colorectal cancer and liver metastases with a focus on terminology, diagnosis and management. Methods: This project was a multi-organisational, multidisciplinary consensus. The consensus group produced statements which focused on terminology, diagnosis and management. Statements were refined during an online Delphi process and those with 70% agreement or above were reviewed at a final meeting. Iterations of the report were shared by electronic mail to arrive at a final agreed document comprising twelve key statements. Results: Synchronous liver metastases are those detected at the time of presentation of the primary tumour. The term “early metachronous metastases” applies to those absent at presentation but detected within 12 months of diagnosis of the primary tumour with “late metachronous metastases” applied to those detected after 12 months. Disappearing metastases applies to lesions which are no longer detectable on MR scan after systemic chemotherapy. Guidance was provided on the recommended composition of tumour boards and clinical assessment in emergency and elective settings. The consensus focused on treatment pathways including systemic chemotherapy, synchronous surgery and the staged approach with either colorectal or liver-directed surgery as first step. Management of pulmonary metastases and the role of minimally invasive surgery was discussed. Conclusions: The recommendations of this contemporary consensus provide information of practical value to clinicians managing patients with synchronous colorectal cancer and liver metastases.
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U2 - 10.1016/j.hpb.2023.05.360
DO - 10.1016/j.hpb.2023.05.360
M3 - Article
C2 - 37442562
AN - SCOPUS:85166950821
SN - 1365-182X
VL - 25
SP - 985
EP - 999
JO - HPB
JF - HPB
IS - 9
ER -