TY - JOUR
T1 - The neuroimmune basis of fatigue
AU - Dantzer, Robert
AU - Heijnen, Cobi Johanna
AU - Kavelaars, Annemieke
AU - Laye, Sophie
AU - Capuron, Lucile
N1 - Funding Information:
Research reported here was supported by the National Institute of Neurological Diseases and Stroke of the National Institutes of Health under award numbers RO1NS073939 and RO1NS074999. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. R.D. is supported by MD Anderson Cancer Center research funds. A.K. is supported by a STARS award of the University of Texas System.
PY - 2014/1
Y1 - 2014/1
N2 - The exact nature and pathophysiology of fatigue remain largely elusive despite its high prevalence in physically ill patients. Studies on the relationship between the immune system and the central nervous system provide a new perspective on the mechanisms of fatigue. Inflammatory mediators that are released by activated innate immune cells at the periphery and in the central nervous system alter the metabolism and activity of neurotransmitters, generate neurotoxic compounds, decrease neurotrophic factors, and profoundly disturb the neuronal environment. The resulting alterations in fronto-striatal networks together with the activation of insula by inflammatory interoceptive stimuli underlie the many dimensions of fatigue including reduced incentive motivation, decreased behavioral flexibility, uncertainty about usefulness of actions, and awareness of fatigue.
AB - The exact nature and pathophysiology of fatigue remain largely elusive despite its high prevalence in physically ill patients. Studies on the relationship between the immune system and the central nervous system provide a new perspective on the mechanisms of fatigue. Inflammatory mediators that are released by activated innate immune cells at the periphery and in the central nervous system alter the metabolism and activity of neurotransmitters, generate neurotoxic compounds, decrease neurotrophic factors, and profoundly disturb the neuronal environment. The resulting alterations in fronto-striatal networks together with the activation of insula by inflammatory interoceptive stimuli underlie the many dimensions of fatigue including reduced incentive motivation, decreased behavioral flexibility, uncertainty about usefulness of actions, and awareness of fatigue.
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U2 - 10.1016/j.tins.2013.10.003
DO - 10.1016/j.tins.2013.10.003
M3 - Review article
C2 - 24239063
AN - SCOPUS:84891373314
SN - 0166-2236
VL - 37
SP - 39
EP - 46
JO - Trends in Neurosciences
JF - Trends in Neurosciences
IS - 1
ER -