The Neuroimmune Regulation and Potential Therapeutic Strategies of Optic Pathway Glioma

Khushboo Irshad; Yu Kai Huang; Paul Rodriguez; Jung Lo; Benjamin E. Aghoghovwia; Yuan Pan; Kun Che Chang

doi:10.3390/brainsci13101424

The Neuroimmune Regulation and Potential Therapeutic Strategies of Optic Pathway Glioma

Khushboo Irshad, Yu Kai Huang, Paul Rodriguez, Jung Lo, Benjamin E. Aghoghovwia, Yuan Pan, Kun Che Chang

Symptom Research CAO

Research output: Contribution to journal › Review article › peer-review

Abstract

Optic pathway glioma (OPG) is one of the causes of pediatric visual impairment. Unfortunately, there is as yet no cure for such a disease. Understanding the underlying mechanisms and the potential therapeutic strategies may help to delay the progression of OPG and rescue the visual morbidities. Here, we provide an overview of preclinical OPG studies and the regulatory pathways controlling OPG pathophysiology. We next discuss the role of microenvironmental cells (neurons, T cells, and tumor-associated microglia and macrophages) in OPG development. Last, we provide insight into potential therapeutic strategies for treating OPG and promoting axon regeneration.

Original language	English (US)
Article number	1424
Journal	Brain Sciences
Volume	13
Issue number	10
DOIs	https://doi.org/10.3390/brainsci13101424
State	Published - Oct 2023

Keywords

cancer neuroscience
neurofibromatosis type 1
optic nerve
optic pathway glioma
T cells
tumor microenvironment
tumor-associated microglia and macrophages

ASJC Scopus subject areas

General Neuroscience

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10.3390/brainsci13101424

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title = "The Neuroimmune Regulation and Potential Therapeutic Strategies of Optic Pathway Glioma",

abstract = "Optic pathway glioma (OPG) is one of the causes of pediatric visual impairment. Unfortunately, there is as yet no cure for such a disease. Understanding the underlying mechanisms and the potential therapeutic strategies may help to delay the progression of OPG and rescue the visual morbidities. Here, we provide an overview of preclinical OPG studies and the regulatory pathways controlling OPG pathophysiology. We next discuss the role of microenvironmental cells (neurons, T cells, and tumor-associated microglia and macrophages) in OPG development. Last, we provide insight into potential therapeutic strategies for treating OPG and promoting axon regeneration.",

keywords = "cancer neuroscience, neurofibromatosis type 1, optic nerve, optic pathway glioma, T cells, tumor microenvironment, tumor-associated microglia and macrophages",

author = "Khushboo Irshad and Huang, {Yu Kai} and Paul Rodriguez and Jung Lo and Aghoghovwia, {Benjamin E.} and Yuan Pan and Chang, {Kun Che}",

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language = "English (US)",

volume = "13",

journal = "Brain Sciences",

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T1 - The Neuroimmune Regulation and Potential Therapeutic Strategies of Optic Pathway Glioma

AU - Irshad, Khushboo

AU - Huang, Yu Kai

AU - Rodriguez, Paul

AU - Lo, Jung

AU - Aghoghovwia, Benjamin E.

AU - Pan, Yuan

AU - Chang, Kun Che

PY - 2023/10

Y1 - 2023/10

N2 - Optic pathway glioma (OPG) is one of the causes of pediatric visual impairment. Unfortunately, there is as yet no cure for such a disease. Understanding the underlying mechanisms and the potential therapeutic strategies may help to delay the progression of OPG and rescue the visual morbidities. Here, we provide an overview of preclinical OPG studies and the regulatory pathways controlling OPG pathophysiology. We next discuss the role of microenvironmental cells (neurons, T cells, and tumor-associated microglia and macrophages) in OPG development. Last, we provide insight into potential therapeutic strategies for treating OPG and promoting axon regeneration.

AB - Optic pathway glioma (OPG) is one of the causes of pediatric visual impairment. Unfortunately, there is as yet no cure for such a disease. Understanding the underlying mechanisms and the potential therapeutic strategies may help to delay the progression of OPG and rescue the visual morbidities. Here, we provide an overview of preclinical OPG studies and the regulatory pathways controlling OPG pathophysiology. We next discuss the role of microenvironmental cells (neurons, T cells, and tumor-associated microglia and macrophages) in OPG development. Last, we provide insight into potential therapeutic strategies for treating OPG and promoting axon regeneration.

KW - cancer neuroscience

KW - neurofibromatosis type 1

KW - optic nerve

KW - optic pathway glioma

KW - T cells

KW - tumor microenvironment

KW - tumor-associated microglia and macrophages

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DO - 10.3390/brainsci13101424

M3 - Review article

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SN - 2076-3425

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JO - Brain Sciences

JF - Brain Sciences

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The Neuroimmune Regulation and Potential Therapeutic Strategies of Optic Pathway Glioma

Abstract

Keywords

ASJC Scopus subject areas

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