TY - JOUR
T1 - The neutrophil-to-lymphocyte ratio
T2 - A narrative review
AU - Faria, Sara Socorro
AU - Fernandes, Paulo César
AU - Silva, Marcelo José Barbosa
AU - Lima, Vladmir C.
AU - Fontes, Wagner
AU - Freitas, Ruffo
AU - Eterovic, Agda Karina
AU - Forget, Patrice
N1 - Publisher Copyright:
© 2017 the authors; licensee ecancermedicalscience.
PY - 2016/12/12
Y1 - 2016/12/12
N2 - Cellular-mediated inflammatory response, lymphocytes, neutrophils, and monocytes are increasingly being recognised as having an important role in tumorigenesis and carcinogenesis. In this context, studies have suggested that the neutrophil-to-lymphocyte ratio (NLR) can be used as an independent prognostic factor in a variety of cancers. Particularly in breast cancer, several studies have shown that a high NLR is associated with shorter survival. Because the NLR can be easily determined from the full blood count, it could potentially provide a simple and inexpensive test cancer prognosis. This review addresses the possibilities and limitations of using the NLR as a clinical tool for risk stratification helpful for individual treatment of breast cancer patients. The potential underlying phenomena and some perspectives are discussed.
AB - Cellular-mediated inflammatory response, lymphocytes, neutrophils, and monocytes are increasingly being recognised as having an important role in tumorigenesis and carcinogenesis. In this context, studies have suggested that the neutrophil-to-lymphocyte ratio (NLR) can be used as an independent prognostic factor in a variety of cancers. Particularly in breast cancer, several studies have shown that a high NLR is associated with shorter survival. Because the NLR can be easily determined from the full blood count, it could potentially provide a simple and inexpensive test cancer prognosis. This review addresses the possibilities and limitations of using the NLR as a clinical tool for risk stratification helpful for individual treatment of breast cancer patients. The potential underlying phenomena and some perspectives are discussed.
KW - Breast cancer
KW - Inflammation
KW - Neutrophil-to-lymphocyte ratio
KW - Prognosis
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U2 - 10.3332/ecancer.2016.702
DO - 10.3332/ecancer.2016.702
M3 - Review article
C2 - 28105073
AN - SCOPUS:85009250645
SN - 1754-6605
VL - 10
JO - ecancermedicalscience
JF - ecancermedicalscience
M1 - 702
ER -