TY - JOUR
T1 - The new world of RNA diagnostics and therapeutics
AU - Blandino, Giovanni
AU - Dinami, Roberto
AU - Marcia, Marco
AU - Anastasiadou, Eleni
AU - Ryan, Brid M.
AU - Palcau, Alina Catalina
AU - Fattore, Luigi
AU - Regazzo, Giulia
AU - Sestito, Rosanna
AU - Loria, Rossella
AU - Díaz Méndez, Ana Belén
AU - Cappelletto, Maria Chiara
AU - Pulito, Claudio
AU - Monteonofrio, Laura
AU - Calin, George A.
AU - Sozzi, Gabriella
AU - Cheong, Jit Kong
AU - Aharonov, Ranit
AU - Ciliberto, Gennaro
N1 - Publisher Copyright:
© 2023, The Author(s).
PY - 2023/12
Y1 - 2023/12
N2 - The 5th Workshop IRE on Translational Oncology was held in Rome (Italy) on 27–28 March at the IRCCS Regina Elena National Cancer Institute. This meeting entitled “The New World of RNA diagnostics and therapeutics” highlightes the significant progress in the RNA field made over the last years. Research moved from pure discovery towards the development of diagnostic biomarkers or RNA-base targeted therapies seeking validation in several clinical trials. Non-coding RNAs in particular have been the focus of this workshop due to their unique properties that make them attractive tools for the diagnosis and therapy of cancer. This report collected the presentations of many scientists from different institutions that discussed recent oncology research providing an excellent overview and representative examples for each possible application of RNA as biomarker, for therapy or to increase the number of patients that can benefit from precision oncology treatment. In particular, the meeting specifically emphasized two key features of RNA applications: RNA diagnostic (Blandino, Palcau, Sestito, Díaz Méndez, Cappelletto, Pulito, Monteonofrio, Calin, Sozzi, Cheong) and RNA therapeutics (Dinami, Marcia, Anastasiadou, Ryan, Fattore, Regazzo, Loria, Aharonov).
AB - The 5th Workshop IRE on Translational Oncology was held in Rome (Italy) on 27–28 March at the IRCCS Regina Elena National Cancer Institute. This meeting entitled “The New World of RNA diagnostics and therapeutics” highlightes the significant progress in the RNA field made over the last years. Research moved from pure discovery towards the development of diagnostic biomarkers or RNA-base targeted therapies seeking validation in several clinical trials. Non-coding RNAs in particular have been the focus of this workshop due to their unique properties that make them attractive tools for the diagnosis and therapy of cancer. This report collected the presentations of many scientists from different institutions that discussed recent oncology research providing an excellent overview and representative examples for each possible application of RNA as biomarker, for therapy or to increase the number of patients that can benefit from precision oncology treatment. In particular, the meeting specifically emphasized two key features of RNA applications: RNA diagnostic (Blandino, Palcau, Sestito, Díaz Méndez, Cappelletto, Pulito, Monteonofrio, Calin, Sozzi, Cheong) and RNA therapeutics (Dinami, Marcia, Anastasiadou, Ryan, Fattore, Regazzo, Loria, Aharonov).
KW - Cell cycle regulation
KW - Epigenetics
KW - RNA evolution
KW - RNA structure
KW - Splicing
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U2 - 10.1186/s13046-023-02752-8
DO - 10.1186/s13046-023-02752-8
M3 - Article
C2 - 37507791
AN - SCOPUS:85165951933
SN - 0392-9078
VL - 42
JO - Journal of Experimental and Clinical Cancer Research
JF - Journal of Experimental and Clinical Cancer Research
IS - 1
M1 - 189
ER -