The NF-κB Pathway and Cancer Stem Cells

Amanda L. Rinkenbaugh; Albert S. Baldwin

doi:10.3390/cells5020016

The NF-κB Pathway and Cancer Stem Cells

Amanda L. Rinkenbaugh, Albert S. Baldwin

Research output: Contribution to journal › Review article › peer-review

204 Scopus citations

Abstract

The NF-κB transcription factor pathway is a crucial regulator of inflammation and immune responses. Additionally, aberrant NF-κB signaling has been identified in many types of cancer. Downstream of key oncogenic pathways, such as RAS, BCR-ABL, and Her2, NF-κB regulates transcription of target genes that promote cell survival and proliferation, inhibit apoptosis, and mediate invasion and metastasis. The cancer stem cell model posits that a subset of tumor cells (cancer stem cells) drive tumor initiation, exhibit resistance to treatment, and promote recurrence and metastasis. This review examines the evidence for a role for NF-κB signaling in cancer stem cell biology.

Original language	English (US)
Journal	Cells
Volume	5
Issue number	2
DOIs	https://doi.org/10.3390/cells5020016
State	Published - Apr 6 2016
Externally published	Yes

Keywords

Cancer
Cancer stem cells
NF-κB
Self-renewal
Tumor-initiating cells

ASJC Scopus subject areas

General Medicine

Access to Document

10.3390/cells5020016

Cite this

@article{6716afdbee7b4bf6bd3b701c73426e1c,

title = "The NF-κB Pathway and Cancer Stem Cells",

abstract = "The NF-κB transcription factor pathway is a crucial regulator of inflammation and immune responses. Additionally, aberrant NF-κB signaling has been identified in many types of cancer. Downstream of key oncogenic pathways, such as RAS, BCR-ABL, and Her2, NF-κB regulates transcription of target genes that promote cell survival and proliferation, inhibit apoptosis, and mediate invasion and metastasis. The cancer stem cell model posits that a subset of tumor cells (cancer stem cells) drive tumor initiation, exhibit resistance to treatment, and promote recurrence and metastasis. This review examines the evidence for a role for NF-κB signaling in cancer stem cell biology.",

keywords = "Cancer, Cancer stem cells, NF-κB, Self-renewal, Tumor-initiating cells",

author = "Rinkenbaugh, {Amanda L.} and Baldwin, {Albert S.}",

note = "Publisher Copyright: {\textcopyright} 1996-2016 MDPI AG (Basel, Switzerland) unless otherwise stated.",

year = "2016",

month = apr,

day = "6",

doi = "10.3390/cells5020016",

language = "English (US)",

volume = "5",

journal = "Cells",

issn = "2073-4409",

publisher = "MDPI Multidisciplinary Digital Publishing Institute",

number = "2",

}

TY - JOUR

T1 - The NF-κB Pathway and Cancer Stem Cells

AU - Rinkenbaugh, Amanda L.

AU - Baldwin, Albert S.

PY - 2016/4/6

Y1 - 2016/4/6

N2 - The NF-κB transcription factor pathway is a crucial regulator of inflammation and immune responses. Additionally, aberrant NF-κB signaling has been identified in many types of cancer. Downstream of key oncogenic pathways, such as RAS, BCR-ABL, and Her2, NF-κB regulates transcription of target genes that promote cell survival and proliferation, inhibit apoptosis, and mediate invasion and metastasis. The cancer stem cell model posits that a subset of tumor cells (cancer stem cells) drive tumor initiation, exhibit resistance to treatment, and promote recurrence and metastasis. This review examines the evidence for a role for NF-κB signaling in cancer stem cell biology.

AB - The NF-κB transcription factor pathway is a crucial regulator of inflammation and immune responses. Additionally, aberrant NF-κB signaling has been identified in many types of cancer. Downstream of key oncogenic pathways, such as RAS, BCR-ABL, and Her2, NF-κB regulates transcription of target genes that promote cell survival and proliferation, inhibit apoptosis, and mediate invasion and metastasis. The cancer stem cell model posits that a subset of tumor cells (cancer stem cells) drive tumor initiation, exhibit resistance to treatment, and promote recurrence and metastasis. This review examines the evidence for a role for NF-κB signaling in cancer stem cell biology.

KW - Cancer

KW - Cancer stem cells

KW - NF-κB

KW - Self-renewal

KW - Tumor-initiating cells

UR - http://www.scopus.com/inward/record.url?scp=85117877852&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85117877852&partnerID=8YFLogxK

U2 - 10.3390/cells5020016

DO - 10.3390/cells5020016

M3 - Review article

C2 - 27058560

AN - SCOPUS:85117877852

SN - 2073-4409

VL - 5

JO - Cells

JF - Cells

IS - 2

ER -

The NF-κB Pathway and Cancer Stem Cells

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this