The nuclear orphan receptor COUP-TFI is important for differentiation of oligodendrocytes

Hideki Yamaguchi; Cheng Zhou; Song Chang Lin; Beatrice Durand; Sophia Y. Tsai; Ming Jer Tsai

doi:10.1016/j.ydbio.2003.10.038

The nuclear orphan receptor COUP-TFI is important for differentiation of oligodendrocytes

Hideki Yamaguchi, Cheng Zhou, Song Chang Lin, Beatrice Durand, Sophia Y. Tsai, Ming Jer Tsai

Translational Molecular Pathology

Research output: Contribution to journal › Article › peer-review

55 Scopus citations

Abstract

We report here that a member of the nuclear hormone receptor superfamily, chicken ovalbumin upstream promoter-transcription factor 1 (COUP-TFI), plays a critical role in glial cell development and subsequent central nervous system myelination. We demonstrate that COUP-TF1 is expressed in cells of oligodendrocyte lineage. Furthermore, we demonstrate that COUP-TFI null mutant mice exhibit delayed axon myelination and increased dysmyelination in the central nervous system. Using in vitro differentiation assays, we show that these myelination defects are due to delays in oligodendrocyte differentiation. Finally, in situ hybridization and transfection analysis suggests that COUP-TFI acts as an upstream regulator of SCIP/Oct-6/Tst-1, a transcription factor involved in axon myelination. Taken together, these results suggest that COUP-TFI is an important regulator of oligodendrocyte differentiation.

Original language	English (US)
Pages (from-to)	238-251
Number of pages	14
Journal	Developmental Biology
Volume	266
Issue number	2
DOIs	https://doi.org/10.1016/j.ydbio.2003.10.038
State	Published - Feb 15 2004

Keywords

Axon myelination
COUP
COUP-TFI
COUP-TFII
Differentiation
Nuclear receptor
OPC
Oct-6
Oligodendrocyte
Optic nerve
Orphan receptor
SCIP
Tst-1

ASJC Scopus subject areas

Molecular Biology
Developmental Biology
Cell Biology

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10.1016/j.ydbio.2003.10.038

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title = "The nuclear orphan receptor COUP-TFI is important for differentiation of oligodendrocytes",

abstract = "We report here that a member of the nuclear hormone receptor superfamily, chicken ovalbumin upstream promoter-transcription factor 1 (COUP-TFI), plays a critical role in glial cell development and subsequent central nervous system myelination. We demonstrate that COUP-TF1 is expressed in cells of oligodendrocyte lineage. Furthermore, we demonstrate that COUP-TFI null mutant mice exhibit delayed axon myelination and increased dysmyelination in the central nervous system. Using in vitro differentiation assays, we show that these myelination defects are due to delays in oligodendrocyte differentiation. Finally, in situ hybridization and transfection analysis suggests that COUP-TFI acts as an upstream regulator of SCIP/Oct-6/Tst-1, a transcription factor involved in axon myelination. Taken together, these results suggest that COUP-TFI is an important regulator of oligodendrocyte differentiation.",

keywords = "Axon myelination, COUP, COUP-TFI, COUP-TFII, Differentiation, Nuclear receptor, OPC, Oct-6, Oligodendrocyte, Optic nerve, Orphan receptor, SCIP, Tst-1",

author = "Hideki Yamaguchi and Cheng Zhou and Lin, {Song Chang} and Beatrice Durand and Tsai, {Sophia Y.} and Tsai, {Ming Jer}",

note = "Funding Information: We thank Jing Xu for assistance in in situ hybridization. We are grateful to Dr. David J. Anderson for the Olig2 probe, Dr. Bill Stallcup for anti-NG2 proteoglycan antibodies, and Dr. John R. Bermingham, Jr., for SCIP/Oct-6/Tst-1. We also like to thank Mr. Kurt Schillinger and Debra Bramblett for helpful discussion. BD was supported by an EMBO Fellowship. This work is supported by grants from the National Institutes of Health to M.J.T (DK45641) and S.Y.T. (DK55636).",

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AU - Yamaguchi, Hideki

AU - Zhou, Cheng

AU - Lin, Song Chang

AU - Durand, Beatrice

AU - Tsai, Sophia Y.

AU - Tsai, Ming Jer

N1 - Funding Information: We thank Jing Xu for assistance in in situ hybridization. We are grateful to Dr. David J. Anderson for the Olig2 probe, Dr. Bill Stallcup for anti-NG2 proteoglycan antibodies, and Dr. John R. Bermingham, Jr., for SCIP/Oct-6/Tst-1. We also like to thank Mr. Kurt Schillinger and Debra Bramblett for helpful discussion. BD was supported by an EMBO Fellowship. This work is supported by grants from the National Institutes of Health to M.J.T (DK45641) and S.Y.T. (DK55636).

PY - 2004/2/15

Y1 - 2004/2/15

N2 - We report here that a member of the nuclear hormone receptor superfamily, chicken ovalbumin upstream promoter-transcription factor 1 (COUP-TFI), plays a critical role in glial cell development and subsequent central nervous system myelination. We demonstrate that COUP-TF1 is expressed in cells of oligodendrocyte lineage. Furthermore, we demonstrate that COUP-TFI null mutant mice exhibit delayed axon myelination and increased dysmyelination in the central nervous system. Using in vitro differentiation assays, we show that these myelination defects are due to delays in oligodendrocyte differentiation. Finally, in situ hybridization and transfection analysis suggests that COUP-TFI acts as an upstream regulator of SCIP/Oct-6/Tst-1, a transcription factor involved in axon myelination. Taken together, these results suggest that COUP-TFI is an important regulator of oligodendrocyte differentiation.

AB - We report here that a member of the nuclear hormone receptor superfamily, chicken ovalbumin upstream promoter-transcription factor 1 (COUP-TFI), plays a critical role in glial cell development and subsequent central nervous system myelination. We demonstrate that COUP-TF1 is expressed in cells of oligodendrocyte lineage. Furthermore, we demonstrate that COUP-TFI null mutant mice exhibit delayed axon myelination and increased dysmyelination in the central nervous system. Using in vitro differentiation assays, we show that these myelination defects are due to delays in oligodendrocyte differentiation. Finally, in situ hybridization and transfection analysis suggests that COUP-TFI acts as an upstream regulator of SCIP/Oct-6/Tst-1, a transcription factor involved in axon myelination. Taken together, these results suggest that COUP-TFI is an important regulator of oligodendrocyte differentiation.

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KW - Differentiation

KW - Nuclear receptor

KW - OPC

KW - Oct-6

KW - Oligodendrocyte

KW - Optic nerve

KW - Orphan receptor

KW - SCIP

KW - Tst-1

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JO - Developmental Biology

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ER -

The nuclear orphan receptor COUP-TFI is important for differentiation of oligodendrocytes

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