Abstract
Background and purpose: To determine the effect of the curvature of Harrison-Anderson-Mick applicators on the dose distribution in high-dose-rate intraoperative radiation therapy (HDR-IORT). Material and methods: Treatment planning was performed with flat applicators using 192Ir as the radioactive source, and dwell times were optimized using dose-point optimization techniques. These optimized dwell times were then used for the curved applicators, and the dose distributions that would actually be delivered to patients were determined. Results: The dose directly below the central catheter was strongly dependent on the curvature of the applicator. Steep parabolic curves caused underdoses of as much as 19% at a point 1 cm from the convex side of the applicator. The rate of dose reduction with increasing distance from the applicator surface was also a function of the curvature of the applicator. Conclusions: The curvature of the applicator profoundly affects dosimetry and can be exploited to optimize coverage of the target during HDR-IORT procedures. To ensure accurate dose delivery, these dose perturbations must be accounted for in the planning process. We recommend maintaining a dosimetry atlas of various applicator sizes and curvatures in addition to one for flat applicators.
Original language | English (US) |
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Pages (from-to) | 207-212 |
Number of pages | 6 |
Journal | Radiotherapy and Oncology |
Volume | 78 |
Issue number | 2 |
DOIs | |
State | Published - Feb 2006 |
Keywords
- Brachytherapy applicator
- HAM applicator
- HDR-IORT
- IORT
- Treatment planning
ASJC Scopus subject areas
- Hematology
- Oncology
- Radiology Nuclear Medicine and imaging