TY - JOUR
T1 - The outs and ins of bacterial type IV secretion substrates
AU - Ding, Zhiyong
AU - Atmakuri, Krishnamohan
AU - Christie, Peter J.
N1 - Funding Information:
We wish to acknowledge the important contributions of all investigators of type IV systems, and we apologize for omissions of data or citation in this review because of space limitations. We thank the members of the laboratory for helpful discussions and critiques of this review. We thank W. Margolin and members of his laboratory for guidance with and use of the Margolin microscopy facility. We gratefully acknowledge the financial support of the NIH for studies in this laboratory of the A. tumefaciens VirB–D4 type IV secretion system.
PY - 2003/11
Y1 - 2003/11
N2 - Bacteria use type IV secretion systems (T4SS) to translocate macromolecular substrates destined for bacterial, plant or human target cells. The T4SS are medically important, contributing to virulence-gene spread, genome plasticity and the alteration of host cellular processes during infection. The T4SS are ancestrally related to bacterial conjugation machines, but present-day functions include (i) conjugal transfer of DNA by cell-to-cell contact, (ii) translocation of effector molecules to eukaryotic target cells, and (iii) DNA uptake from or release to the extracellular milieu. Rapid progress has been made toward identification of type IV secretion substrates and the requirements for substrate recognition.
AB - Bacteria use type IV secretion systems (T4SS) to translocate macromolecular substrates destined for bacterial, plant or human target cells. The T4SS are medically important, contributing to virulence-gene spread, genome plasticity and the alteration of host cellular processes during infection. The T4SS are ancestrally related to bacterial conjugation machines, but present-day functions include (i) conjugal transfer of DNA by cell-to-cell contact, (ii) translocation of effector molecules to eukaryotic target cells, and (iii) DNA uptake from or release to the extracellular milieu. Rapid progress has been made toward identification of type IV secretion substrates and the requirements for substrate recognition.
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U2 - 10.1016/j.tim.2003.09.004
DO - 10.1016/j.tim.2003.09.004
M3 - Review article
C2 - 14607070
AN - SCOPUS:0242384036
SN - 0966-842X
VL - 11
SP - 527
EP - 535
JO - Trends in Microbiology
JF - Trends in Microbiology
IS - 11
ER -