Abstract
The p53 protein can bind to a set of specific DNA sequences, and this may activate the transcription of genes adjacent to these DNA elements. The mdm-2 gene is shown here to contain a p53 DNA-binding site and a genetically responsive element such that expression of the mdm-2 gene can be regulated by the level of wild-type p53 protein. The mdm-2 protein, in turn, can complex with p53 and decrease its ability to act as a positive transcription factor at the mdm-2 gene-responsive element. In this way, the mdm-2 gene is autoregulated. The p53 protein regulates the mdm-2 gene at the level of transcription, and the mdm-2 protein regulates the p53 protein at the level of its activity. This creates a feedback loop that regulates both the activity of the p53 protein and the expression of the mdm-2 gene.
Original language | English (US) |
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Pages (from-to) | 1126-1132 |
Number of pages | 7 |
Journal | Genes and Development |
Volume | 7 |
Issue number | 7 |
State | Published - 1993 |
Externally published | Yes |
ASJC Scopus subject areas
- Genetics
- Developmental Biology