The potential of biology-guided radiation therapy in thoracic cancer: A preliminary treatment planning study

Steven N. Seyedin; Rostem Bassalow; Osama R. Mawlawi; Lehendrick M. Turner; Roshal R. Patel; Samuel R. Mazin; Oluwaseyi M. Oderinde; Yevgen Voronenko; Cody A. Wages; Peter D. Olcott; Joe Y. Chang; Peter A. Balter; James W. Welsh

doi:10.3389/fonc.2022.921473

The potential of biology-guided radiation therapy in thoracic cancer: A preliminary treatment planning study

Steven N. Seyedin, Rostem Bassalow, Osama R. Mawlawi, Lehendrick M. Turner, Roshal R. Patel, Samuel R. Mazin, Oluwaseyi M. Oderinde, Yevgen Voronenko, Cody A. Wages, Peter D. Olcott, Joe Y. Chang, Peter A. Balter, James W. Welsh

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Purpose: We investigated the feasibility of biology-guided radiotherapy (BgRT), a technique that utilizes real-time positron emission imaging to minimize tumor motion uncertainties, to spare nearby organs at risk. Methods: Volumetric modulated arc therapy (VMAT), intensity-modulated proton (IMPT) therapy, and BgRT plans were created for a paratracheal node recurrence (case 1; 60 Gy in 10 fractions) and a primary peripheral left upper lobe adenocarcinoma (case 2; 50 Gy in four fractions). Results: For case 1, BgRT produced lower bronchus V40 values compared to VMAT and IMPT. For case 2, total lung V20 was lower in the BgRT case compared to VMAT and IMPT. Conclusions: BgRT has the potential to reduce the radiation dose to proximal critical structures but requires further detailed investigation.

Original language	English (US)
Article number	921473
Journal	Frontiers in Oncology
Volume	12
DOIs	https://doi.org/10.3389/fonc.2022.921473
State	Published - Oct 14 2022

Keywords

BgRT
PET guidance
radiation therapy
stereotactic radiotherapy
thoracic cancer

ASJC Scopus subject areas

Oncology
Cancer Research

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10.3389/fonc.2022.921473

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Seyedin, S. N., Bassalow, R., Mawlawi, O. R., Turner, L. M., Patel, R. R., Mazin, S. R., Oderinde, O. M., Voronenko, Y., Wages, C. A., Olcott, P. D., Chang, J. Y., Balter, P. A., & Welsh, J. W. (2022). The potential of biology-guided radiation therapy in thoracic cancer: A preliminary treatment planning study. Frontiers in Oncology, 12, Article 921473. https://doi.org/10.3389/fonc.2022.921473

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title = "The potential of biology-guided radiation therapy in thoracic cancer: A preliminary treatment planning study",

abstract = "Purpose: We investigated the feasibility of biology-guided radiotherapy (BgRT), a technique that utilizes real-time positron emission imaging to minimize tumor motion uncertainties, to spare nearby organs at risk. Methods: Volumetric modulated arc therapy (VMAT), intensity-modulated proton (IMPT) therapy, and BgRT plans were created for a paratracheal node recurrence (case 1; 60 Gy in 10 fractions) and a primary peripheral left upper lobe adenocarcinoma (case 2; 50 Gy in four fractions). Results: For case 1, BgRT produced lower bronchus V40 values compared to VMAT and IMPT. For case 2, total lung V20 was lower in the BgRT case compared to VMAT and IMPT. Conclusions: BgRT has the potential to reduce the radiation dose to proximal critical structures but requires further detailed investigation.",

keywords = "BgRT, PET guidance, radiation therapy, stereotactic radiotherapy, thoracic cancer",

author = "Seyedin, {Steven N.} and Rostem Bassalow and Mawlawi, {Osama R.} and Turner, {Lehendrick M.} and Patel, {Roshal R.} and Mazin, {Samuel R.} and Oderinde, {Oluwaseyi M.} and Yevgen Voronenko and Wages, {Cody A.} and Olcott, {Peter D.} and Chang, {Joe Y.} and Balter, {Peter A.} and Welsh, {James W.}",

note = "Publisher Copyright: Copyright {\textcopyright} 2022 Seyedin, Bassalow, Mawlawi, Turner, Patel, Mazin, Oderinde, Voronenko, Wages, Olcott, Chang, Balter and Welsh.",

year = "2022",

month = oct,

day = "14",

doi = "10.3389/fonc.2022.921473",

language = "English (US)",

volume = "12",

journal = "Frontiers in Oncology",

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T2 - A preliminary treatment planning study

AU - Seyedin, Steven N.

AU - Bassalow, Rostem

AU - Mawlawi, Osama R.

AU - Turner, Lehendrick M.

AU - Patel, Roshal R.

AU - Mazin, Samuel R.

AU - Oderinde, Oluwaseyi M.

AU - Voronenko, Yevgen

AU - Wages, Cody A.

AU - Olcott, Peter D.

AU - Chang, Joe Y.

AU - Balter, Peter A.

AU - Welsh, James W.

PY - 2022/10/14

Y1 - 2022/10/14

N2 - Purpose: We investigated the feasibility of biology-guided radiotherapy (BgRT), a technique that utilizes real-time positron emission imaging to minimize tumor motion uncertainties, to spare nearby organs at risk. Methods: Volumetric modulated arc therapy (VMAT), intensity-modulated proton (IMPT) therapy, and BgRT plans were created for a paratracheal node recurrence (case 1; 60 Gy in 10 fractions) and a primary peripheral left upper lobe adenocarcinoma (case 2; 50 Gy in four fractions). Results: For case 1, BgRT produced lower bronchus V40 values compared to VMAT and IMPT. For case 2, total lung V20 was lower in the BgRT case compared to VMAT and IMPT. Conclusions: BgRT has the potential to reduce the radiation dose to proximal critical structures but requires further detailed investigation.

AB - Purpose: We investigated the feasibility of biology-guided radiotherapy (BgRT), a technique that utilizes real-time positron emission imaging to minimize tumor motion uncertainties, to spare nearby organs at risk. Methods: Volumetric modulated arc therapy (VMAT), intensity-modulated proton (IMPT) therapy, and BgRT plans were created for a paratracheal node recurrence (case 1; 60 Gy in 10 fractions) and a primary peripheral left upper lobe adenocarcinoma (case 2; 50 Gy in four fractions). Results: For case 1, BgRT produced lower bronchus V40 values compared to VMAT and IMPT. For case 2, total lung V20 was lower in the BgRT case compared to VMAT and IMPT. Conclusions: BgRT has the potential to reduce the radiation dose to proximal critical structures but requires further detailed investigation.

KW - BgRT

KW - PET guidance

KW - radiation therapy

KW - stereotactic radiotherapy

KW - thoracic cancer

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The potential of biology-guided radiation therapy in thoracic cancer: A preliminary treatment planning study

Abstract

Keywords

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