The potential use of liposome-mediated antiviral therapy

Wayne C. Koff; Isaiah J. Fidler

doi:10.1016/0166-3542(85)90050-6

The potential use of liposome-mediated antiviral therapy

Wayne C. Koff, Isaiah J. Fidler

Cancer Biology

Research output: Contribution to journal › Review article › peer-review

31 Scopus citations

Abstract

The natural targeting of liposomes to cells of the reticuloendothelial system should be exploited to examine whether selective delivery of antiviral or immunomodulatory agents could be beneficial for the treatment of viral diseases. In this review we discuss the potential use of liposomes in the treatment of virus diseases, the targeting of liposome-encapsulated immunomodulators to macrophages in order to render these cells cytolytic for virus-infected cells, and the targeting of liposome-encapsulated antiviral drugs to macrophages to achieve direct suppression of virus replication within these cells.

Original language	English (US)
Pages (from-to)	179-190
Number of pages	12
Journal	Antiviral Research
Volume	5
Issue number	3
DOIs	https://doi.org/10.1016/0166-3542(85)90050-6
State	Published - Jun 1985

Keywords

drug targeting
liposomes
macrophage activation

ASJC Scopus subject areas

Pharmacology
Virology

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10.1016/0166-3542(85)90050-6

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title = "The potential use of liposome-mediated antiviral therapy",

abstract = "The natural targeting of liposomes to cells of the reticuloendothelial system should be exploited to examine whether selective delivery of antiviral or immunomodulatory agents could be beneficial for the treatment of viral diseases. In this review we discuss the potential use of liposomes in the treatment of virus diseases, the targeting of liposome-encapsulated immunomodulators to macrophages in order to render these cells cytolytic for virus-infected cells, and the targeting of liposome-encapsulated antiviral drugs to macrophages to achieve direct suppression of virus replication within these cells.",

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AU - Fidler, Isaiah J.

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AB - The natural targeting of liposomes to cells of the reticuloendothelial system should be exploited to examine whether selective delivery of antiviral or immunomodulatory agents could be beneficial for the treatment of viral diseases. In this review we discuss the potential use of liposomes in the treatment of virus diseases, the targeting of liposome-encapsulated immunomodulators to macrophages in order to render these cells cytolytic for virus-infected cells, and the targeting of liposome-encapsulated antiviral drugs to macrophages to achieve direct suppression of virus replication within these cells.

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KW - liposomes

KW - macrophage activation

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SP - 179

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JO - Antiviral Research

JF - Antiviral Research

IS - 3

ER -

The potential use of liposome-mediated antiviral therapy

Abstract

Keywords

ASJC Scopus subject areas

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