The prognostic impact of body composition for locally advanced breast cancer patients who received neoadjuvant chemotherapy

Toshiaki Iwase; Aaroh Parikh; Seyedeh S. Dibaj; Yu Shen; Tushaar Vishal Shrimanker; Sudpreeda Chainitikun; Kumiko Kida; Maryanne E. Sapon; Onur Sahin; Anjali James; Andrea Yizel Delgado Medrano; Ann H. Klopp; Naoto T. Ueno

doi:10.3390/cancers13040608

The prognostic impact of body composition for locally advanced breast cancer patients who received neoadjuvant chemotherapy

Toshiaki Iwase, Aaroh Parikh, Seyedeh S. Dibaj, Yu Shen, Tushaar Vishal Shrimanker, Sudpreeda Chainitikun, Kumiko Kida, Maryanne E. Sapon, Onur Sahin, Anjali James, Andrea Yizel Delgado Medrano, Ann H. Klopp, Naoto T. Ueno

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Our previous study indicated that a high amount of visceral adipose tissue was associated with poor survival outcomes in patients with early breast cancer who received neoadjuvant chemotherapy. However, inconsistency was observed in the prognostic role of body composition in breast cancer treatment outcomes. In the present study, we aimed to validate our previous research by performing a comprehensive body composition analysis in patients with a standardized clinical background. We included 198 patients with stage III breast cancer who underwent neoadjuvant chemotherapy between January 2007 and June 2015. The impact of body composition on pathologic complete response and survival outcomes was determined. Body composition measurements had no significant effect on pathologic complete response. Survival analysis showed a low ratio of total visceral adipose tissue to subcutaneous adipose tissue (V/S ratio ≤ 34) was associated with shorter overall survival. A changepoint method determined that a V/S ratio cutoff of 34 maximized the difference in overall survival. Our study indicated the prognostic effect of body composition measurements in patients with locally advanced breast cancer compared to those with early breast cancer. Further investigation will be needed to clarify the biological mechanism underlying the association of V/S ratio with prognosis in locally advanced breast cancer.

Original language	English (US)
Article number	608
Pages (from-to)	1-11
Number of pages	11
Journal	Cancers
Volume	13
Issue number	4
DOIs	https://doi.org/10.3390/cancers13040608
State	Published - Feb 2 2021

Keywords

Body composition
Breast neoplasm
Computed tomography
Obesity
Pathologic complete response

ASJC Scopus subject areas

Oncology
Cancer Research

MD Anderson CCSG core facilities

Biostatistics Resource Group

Access to Document

10.3390/cancers13040608

Cite this

Iwase, T., Parikh, A., Dibaj, S. S., Shen, Y., Shrimanker, T. V., Chainitikun, S., Kida, K., Sapon, M. E., Sahin, O., James, A., Medrano, A. Y. D., Klopp, A. H., & Ueno, N. T. (2021). The prognostic impact of body composition for locally advanced breast cancer patients who received neoadjuvant chemotherapy. Cancers, 13(4), 1-11. Article 608. https://doi.org/10.3390/cancers13040608

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title = "The prognostic impact of body composition for locally advanced breast cancer patients who received neoadjuvant chemotherapy",

abstract = "Our previous study indicated that a high amount of visceral adipose tissue was associated with poor survival outcomes in patients with early breast cancer who received neoadjuvant chemotherapy. However, inconsistency was observed in the prognostic role of body composition in breast cancer treatment outcomes. In the present study, we aimed to validate our previous research by performing a comprehensive body composition analysis in patients with a standardized clinical background. We included 198 patients with stage III breast cancer who underwent neoadjuvant chemotherapy between January 2007 and June 2015. The impact of body composition on pathologic complete response and survival outcomes was determined. Body composition measurements had no significant effect on pathologic complete response. Survival analysis showed a low ratio of total visceral adipose tissue to subcutaneous adipose tissue (V/S ratio ≤ 34) was associated with shorter overall survival. A changepoint method determined that a V/S ratio cutoff of 34 maximized the difference in overall survival. Our study indicated the prognostic effect of body composition measurements in patients with locally advanced breast cancer compared to those with early breast cancer. Further investigation will be needed to clarify the biological mechanism underlying the association of V/S ratio with prognosis in locally advanced breast cancer.",

keywords = "Body composition, Breast neoplasm, Computed tomography, Obesity, Pathologic complete response",

author = "Toshiaki Iwase and Aaroh Parikh and Dibaj, {Seyedeh S.} and Yu Shen and Shrimanker, {Tushaar Vishal} and Sudpreeda Chainitikun and Kumiko Kida and Sapon, {Maryanne E.} and Onur Sahin and Anjali James and Medrano, {Andrea Yizel Delgado} and Klopp, {Ann H.} and Ueno, {Naoto T.}",

note = "Funding Information: This work was supported by the Morgan Welch Inflammatory Breast Cancer Research Program, a State of Texas Rare and Aggressive Breast Cancer Research Program grant, National Institutes of Health/National Cancer Institute award 1R01CA205043-01A1 (to N.T.U.). Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",

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doi = "10.3390/cancers13040608",

language = "English (US)",

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AU - Iwase, Toshiaki

AU - Parikh, Aaroh

AU - Dibaj, Seyedeh S.

AU - Shen, Yu

AU - Shrimanker, Tushaar Vishal

AU - Chainitikun, Sudpreeda

AU - Kida, Kumiko

AU - Sapon, Maryanne E.

AU - Sahin, Onur

AU - James, Anjali

AU - Medrano, Andrea Yizel Delgado

AU - Klopp, Ann H.

AU - Ueno, Naoto T.

N1 - Funding Information: This work was supported by the Morgan Welch Inflammatory Breast Cancer Research Program, a State of Texas Rare and Aggressive Breast Cancer Research Program grant, National Institutes of Health/National Cancer Institute award 1R01CA205043-01A1 (to N.T.U.). Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.

PY - 2021/2/2

Y1 - 2021/2/2

N2 - Our previous study indicated that a high amount of visceral adipose tissue was associated with poor survival outcomes in patients with early breast cancer who received neoadjuvant chemotherapy. However, inconsistency was observed in the prognostic role of body composition in breast cancer treatment outcomes. In the present study, we aimed to validate our previous research by performing a comprehensive body composition analysis in patients with a standardized clinical background. We included 198 patients with stage III breast cancer who underwent neoadjuvant chemotherapy between January 2007 and June 2015. The impact of body composition on pathologic complete response and survival outcomes was determined. Body composition measurements had no significant effect on pathologic complete response. Survival analysis showed a low ratio of total visceral adipose tissue to subcutaneous adipose tissue (V/S ratio ≤ 34) was associated with shorter overall survival. A changepoint method determined that a V/S ratio cutoff of 34 maximized the difference in overall survival. Our study indicated the prognostic effect of body composition measurements in patients with locally advanced breast cancer compared to those with early breast cancer. Further investigation will be needed to clarify the biological mechanism underlying the association of V/S ratio with prognosis in locally advanced breast cancer.

AB - Our previous study indicated that a high amount of visceral adipose tissue was associated with poor survival outcomes in patients with early breast cancer who received neoadjuvant chemotherapy. However, inconsistency was observed in the prognostic role of body composition in breast cancer treatment outcomes. In the present study, we aimed to validate our previous research by performing a comprehensive body composition analysis in patients with a standardized clinical background. We included 198 patients with stage III breast cancer who underwent neoadjuvant chemotherapy between January 2007 and June 2015. The impact of body composition on pathologic complete response and survival outcomes was determined. Body composition measurements had no significant effect on pathologic complete response. Survival analysis showed a low ratio of total visceral adipose tissue to subcutaneous adipose tissue (V/S ratio ≤ 34) was associated with shorter overall survival. A changepoint method determined that a V/S ratio cutoff of 34 maximized the difference in overall survival. Our study indicated the prognostic effect of body composition measurements in patients with locally advanced breast cancer compared to those with early breast cancer. Further investigation will be needed to clarify the biological mechanism underlying the association of V/S ratio with prognosis in locally advanced breast cancer.

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KW - Breast neoplasm

KW - Computed tomography

KW - Obesity

KW - Pathologic complete response

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The prognostic impact of body composition for locally advanced breast cancer patients who received neoadjuvant chemotherapy

Abstract

Keywords

ASJC Scopus subject areas

MD Anderson CCSG core facilities

Access to Document

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