The Prognostic Role of Human Papillomavirus and p16 Status in Penile Squamous Cell Carcinoma—A Systematic Review

Kevin Parza; Arfa Mustasam; Filip Ionescu; Mahati Paravathaneni; Reagan Sandstrom; Houssein Safa; G. Daniel Grass; Peter A. Johnstone; Steven A. Eschrich; Juskaran Chadha; Niki Zacharias; Curtis A. Pettaway; Philippe E. Spiess; Jad Chahoud

doi:10.3390/cancers15143713

The Prognostic Role of Human Papillomavirus and p16 Status in Penile Squamous Cell Carcinoma—A Systematic Review

Kevin Parza, Arfa Mustasam, Filip Ionescu, Mahati Paravathaneni, Reagan Sandstrom, Houssein Safa, G. Daniel Grass, Peter A. Johnstone, Steven A. Eschrich, Juskaran Chadha, Niki Zacharias, Curtis A. Pettaway, Philippe E. Spiess, Jad Chahoud

Urology

Research output: Contribution to journal › Review article › peer-review

6 Scopus citations

Abstract

PSCC is a rare cancer, with approximately half of all cases related to HPV. While HPV and p16 IHC testing have proven their prognostic value for oropharyngeal cancer, this is not yet established for PSCC. The current level of evidence exploring the relation between PSCC and HPV is moderate, so we conducted a systematic review following PRISMA guidelines to evaluate the prognostic role of HPV and p16 IHC in PSCC clinical outcomes. We searched the PubMed, Embase, and Cochrane databases and identified 34 relevant studies that met our inclusion criteria. Of these, 33 were retrospective cohort studies, and one was a cross-sectional study. Nine studies reported that HPV-positive and p16-positive PSCC had better overall survival (OS) and disease-free survival (DFS). This study highlights the need for a meta-analysis to determine the role of routine HPV status or p16 staining testing as part of the initial diagnosis and staging of PSCC patients worldwide.

Original language	English (US)
Article number	3713
Journal	Cancers
Volume	15
Issue number	14
DOIs	https://doi.org/10.3390/cancers15143713
State	Published - Jul 2023

Keywords

HPV-related cancers
human papillomavirus
p16
penile cancer
rare cancers

ASJC Scopus subject areas

Oncology
Cancer Research

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10.3390/cancers15143713

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Parza, K., Mustasam, A., Ionescu, F., Paravathaneni, M., Sandstrom, R., Safa, H., Grass, G. D., Johnstone, P. A., Eschrich, S. A., Chadha, J., Zacharias, N., Pettaway, C. A., Spiess, P. E., & Chahoud, J. (2023). The Prognostic Role of Human Papillomavirus and p16 Status in Penile Squamous Cell Carcinoma—A Systematic Review. Cancers, 15(14), Article 3713. https://doi.org/10.3390/cancers15143713

Parza, K, Mustasam, A, Ionescu, F, Paravathaneni, M, Sandstrom, R, Safa, H, Grass, GD, Johnstone, PA, Eschrich, SA, Chadha, J, Zacharias, N , Pettaway, CA, Spiess, PE & Chahoud, J 2023, 'The Prognostic Role of Human Papillomavirus and p16 Status in Penile Squamous Cell Carcinoma—A Systematic Review', Cancers, vol. 15, no. 14, 3713. https://doi.org/10.3390/cancers15143713

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title = "The Prognostic Role of Human Papillomavirus and p16 Status in Penile Squamous Cell Carcinoma—A Systematic Review",

abstract = "PSCC is a rare cancer, with approximately half of all cases related to HPV. While HPV and p16 IHC testing have proven their prognostic value for oropharyngeal cancer, this is not yet established for PSCC. The current level of evidence exploring the relation between PSCC and HPV is moderate, so we conducted a systematic review following PRISMA guidelines to evaluate the prognostic role of HPV and p16 IHC in PSCC clinical outcomes. We searched the PubMed, Embase, and Cochrane databases and identified 34 relevant studies that met our inclusion criteria. Of these, 33 were retrospective cohort studies, and one was a cross-sectional study. Nine studies reported that HPV-positive and p16-positive PSCC had better overall survival (OS) and disease-free survival (DFS). This study highlights the need for a meta-analysis to determine the role of routine HPV status or p16 staining testing as part of the initial diagnosis and staging of PSCC patients worldwide.",

keywords = "HPV-related cancers, human papillomavirus, p16, penile cancer, rare cancers",

author = "Kevin Parza and Arfa Mustasam and Filip Ionescu and Mahati Paravathaneni and Reagan Sandstrom and Houssein Safa and Grass, {G. Daniel} and Johnstone, {Peter A.} and Eschrich, {Steven A.} and Juskaran Chadha and Niki Zacharias and Pettaway, {Curtis A.} and Spiess, {Philippe E.} and Jad Chahoud",

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year = "2023",

month = jul,

doi = "10.3390/cancers15143713",

language = "English (US)",

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AU - Parza, Kevin

AU - Mustasam, Arfa

AU - Ionescu, Filip

AU - Paravathaneni, Mahati

AU - Sandstrom, Reagan

AU - Safa, Houssein

AU - Grass, G. Daniel

AU - Johnstone, Peter A.

AU - Eschrich, Steven A.

AU - Chadha, Juskaran

AU - Zacharias, Niki

AU - Pettaway, Curtis A.

AU - Spiess, Philippe E.

AU - Chahoud, Jad

PY - 2023/7

Y1 - 2023/7

N2 - PSCC is a rare cancer, with approximately half of all cases related to HPV. While HPV and p16 IHC testing have proven their prognostic value for oropharyngeal cancer, this is not yet established for PSCC. The current level of evidence exploring the relation between PSCC and HPV is moderate, so we conducted a systematic review following PRISMA guidelines to evaluate the prognostic role of HPV and p16 IHC in PSCC clinical outcomes. We searched the PubMed, Embase, and Cochrane databases and identified 34 relevant studies that met our inclusion criteria. Of these, 33 were retrospective cohort studies, and one was a cross-sectional study. Nine studies reported that HPV-positive and p16-positive PSCC had better overall survival (OS) and disease-free survival (DFS). This study highlights the need for a meta-analysis to determine the role of routine HPV status or p16 staining testing as part of the initial diagnosis and staging of PSCC patients worldwide.

AB - PSCC is a rare cancer, with approximately half of all cases related to HPV. While HPV and p16 IHC testing have proven their prognostic value for oropharyngeal cancer, this is not yet established for PSCC. The current level of evidence exploring the relation between PSCC and HPV is moderate, so we conducted a systematic review following PRISMA guidelines to evaluate the prognostic role of HPV and p16 IHC in PSCC clinical outcomes. We searched the PubMed, Embase, and Cochrane databases and identified 34 relevant studies that met our inclusion criteria. Of these, 33 were retrospective cohort studies, and one was a cross-sectional study. Nine studies reported that HPV-positive and p16-positive PSCC had better overall survival (OS) and disease-free survival (DFS). This study highlights the need for a meta-analysis to determine the role of routine HPV status or p16 staining testing as part of the initial diagnosis and staging of PSCC patients worldwide.

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KW - human papillomavirus

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KW - penile cancer

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The Prognostic Role of Human Papillomavirus and p16 Status in Penile Squamous Cell Carcinoma—A Systematic Review

Abstract

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