TY - JOUR
T1 - The prognostic significance of peritoneal cytology for stage i endometrial cancer
AU - Turner, Deborah A.
AU - Gershenson, David M.
AU - Atkinson, Neely
AU - Sneige, Nour
AU - Wharton, A. Taylor
PY - 1989/11
Y1 - 1989/11
N2 - A retrospective study of 567 patients treated for surgical stage I endometrial cancer was undertaken to resolve the controversy over the significance of malignant peritoneal cytology findings in early-stage disease. Twenty-eight women (4.9%) had peritoneal cytology positive for malignant cells. Comparisons were made between the groups with positive and negative cytology. Subgroups used in analysis included stage according to the International Federation of Gynecology and Obstetrics, treatment regimen, histology, grade, depth of myometrial invasion, and cervical Papanicolaou smear results. Cervical smear status was the only subgroup in which a statistically significant difference was found, with the positive peritoneal cytology patients having a higher incidence of positive Papanicolaou smears (P=.01). Forty-nine women (8.6%) developed recurrent tumor, 7% of the negative-cytology group and 32% of the positive-cytology group (P=.0002). The progression-free survival rate was lowered significantly by positive peritoneal cytology (P<.0001); patients with negative peritoneal cytology had a significantly better 5-year survival rate, 96 versus 84% (P=.0001). When multivariate analysis was performed on the 477 cases that had no missing values, peritoneal cytology remained significant for both survival rate (P=.01) and progression-free interval (P=.002). Positive peritoneal cytology is a poor prognostic factor for patients with surgical stage I endometrial cancer.
AB - A retrospective study of 567 patients treated for surgical stage I endometrial cancer was undertaken to resolve the controversy over the significance of malignant peritoneal cytology findings in early-stage disease. Twenty-eight women (4.9%) had peritoneal cytology positive for malignant cells. Comparisons were made between the groups with positive and negative cytology. Subgroups used in analysis included stage according to the International Federation of Gynecology and Obstetrics, treatment regimen, histology, grade, depth of myometrial invasion, and cervical Papanicolaou smear results. Cervical smear status was the only subgroup in which a statistically significant difference was found, with the positive peritoneal cytology patients having a higher incidence of positive Papanicolaou smears (P=.01). Forty-nine women (8.6%) developed recurrent tumor, 7% of the negative-cytology group and 32% of the positive-cytology group (P=.0002). The progression-free survival rate was lowered significantly by positive peritoneal cytology (P<.0001); patients with negative peritoneal cytology had a significantly better 5-year survival rate, 96 versus 84% (P=.0001). When multivariate analysis was performed on the 477 cases that had no missing values, peritoneal cytology remained significant for both survival rate (P=.01) and progression-free interval (P=.002). Positive peritoneal cytology is a poor prognostic factor for patients with surgical stage I endometrial cancer.
UR - http://www.scopus.com/inward/record.url?scp=0024456560&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0024456560&partnerID=8YFLogxK
M3 - Article
C2 - 2812655
AN - SCOPUS:0024456560
SN - 0029-7844
VL - 74
SP - 775
EP - 780
JO - Obstetrics and gynecology
JF - Obstetrics and gynecology
IS - 5
ER -