TY - JOUR
T1 - The promise of patient-derived xenografts
T2 - The best laid plans of mice and men
AU - Kopetz, Scott
AU - Lemos, Robert
AU - Powis, Garth
PY - 2012/10/1
Y1 - 2012/10/1
N2 - Compared with xenografts from previously established cell lines, patient-derived xenografts may more faithfully recapitulate the molecular diversity, cellular heterogeneity, and histology seen in patient tumors, although other limitations of murine models remain. The ability of these models to inform clinical development and answer mechanistic questions will determine their ultimate use.
AB - Compared with xenografts from previously established cell lines, patient-derived xenografts may more faithfully recapitulate the molecular diversity, cellular heterogeneity, and histology seen in patient tumors, although other limitations of murine models remain. The ability of these models to inform clinical development and answer mechanistic questions will determine their ultimate use.
UR - http://www.scopus.com/inward/record.url?scp=84866950018&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84866950018&partnerID=8YFLogxK
U2 - 10.1158/1078-0432.CCR-12-2408
DO - 10.1158/1078-0432.CCR-12-2408
M3 - Comment/debate
C2 - 22912394
AN - SCOPUS:84866950018
SN - 1078-0432
VL - 18
SP - 5160
EP - 5162
JO - Clinical Cancer Research
JF - Clinical Cancer Research
IS - 19
ER -