TY - JOUR
T1 - The pulmonary vascular bed in children with Down syndrome
AU - Chi, Tzeh Ping L.
AU - Krovetz, L. Jerome
N1 - Funding Information:
From the Departments of Pediatrics and Biomedical Engineering, The Johns Hopkins University School of Medicine. Supported in part by a research grant from NHL1 (HL 13679-03) and (RR-52) from the General Clinical Research Centers Program of the Division of Research Resources, National Institutes of Health. *Reprint address: Department of Pediatrics, University of Virginia Hospital Charlottesville, Va. 22901.
PY - 1975/4
Y1 - 1975/4
N2 - Sixty-nine children with Down syndrome (mongolism, trisomy 21), with atrial septal defect, patent ductus arteriosus, ventricular septal defect, or endocardial cushion defects, and 315 children with similar cardiac anomalies without this syndrome underwent cardiac catheterization during an 8-year period from 1964 to 1973. Only patients under 17 years of age were included in the study. Nine tenths of the children with Down syndrome but only one fourth of the control group had abnormally high pulmonary arterial pressures. For example, 9 of 11 children with defects of the atrial septum and Down syndrome had pulmonary hypertension; in contrast, only 5 of 55 control subjects with similar defects had pulmonary hypertension. The data suggest that children with congenital heart disease and Down syndrome have an unusually high pulmonary vascular resistance and a propensity for early development of severe damage to the pulmonary vascular bed.
AB - Sixty-nine children with Down syndrome (mongolism, trisomy 21), with atrial septal defect, patent ductus arteriosus, ventricular septal defect, or endocardial cushion defects, and 315 children with similar cardiac anomalies without this syndrome underwent cardiac catheterization during an 8-year period from 1964 to 1973. Only patients under 17 years of age were included in the study. Nine tenths of the children with Down syndrome but only one fourth of the control group had abnormally high pulmonary arterial pressures. For example, 9 of 11 children with defects of the atrial septum and Down syndrome had pulmonary hypertension; in contrast, only 5 of 55 control subjects with similar defects had pulmonary hypertension. The data suggest that children with congenital heart disease and Down syndrome have an unusually high pulmonary vascular resistance and a propensity for early development of severe damage to the pulmonary vascular bed.
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U2 - 10.1016/S0022-3476(75)80142-9
DO - 10.1016/S0022-3476(75)80142-9
M3 - Article
C2 - 123955
AN - SCOPUS:0016832302
SN - 0022-3476
VL - 86
SP - 533
EP - 538
JO - The Journal of Pediatrics
JF - The Journal of Pediatrics
IS - 4
ER -