The pyrimidinosome: Orchestrating pyrimidine biosynthesis and ferroptosis defense

Boyi Gan

doi:10.1016/j.molcel.2023.07.013

The pyrimidinosome: Orchestrating pyrimidine biosynthesis and ferroptosis defense

Boyi Gan

Experimental Radiation Oncology

Research output: Contribution to journal › Comment/debate › peer-review

Abstract

A recent study by Yang et al.¹ uncovers the pyrimidinosome, a multienzyme complex where enzymes from different subcellular compartments collaborate to enable efficient pyrimidine biosynthesis and ferroptosis defense, highlighting the remarkable adaptability of cellular metabolism and new therapeutic opportunities.

Original language	English (US)
Pages (from-to)	2837-2839
Number of pages	3
Journal	Molecular cell
Volume	83
Issue number	16
DOIs	https://doi.org/10.1016/j.molcel.2023.07.013
State	Published - Aug 17 2023

ASJC Scopus subject areas

Molecular Biology
Cell Biology

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10.1016/j.molcel.2023.07.013

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title = "The pyrimidinosome: Orchestrating pyrimidine biosynthesis and ferroptosis defense",

abstract = "A recent study by Yang et al.1 uncovers the pyrimidinosome, a multienzyme complex where enzymes from different subcellular compartments collaborate to enable efficient pyrimidine biosynthesis and ferroptosis defense, highlighting the remarkable adaptability of cellular metabolism and new therapeutic opportunities.",

author = "Boyi Gan",

note = "Publisher Copyright: {\textcopyright} 2023 Elsevier Inc.",

year = "2023",

month = aug,

day = "17",

doi = "10.1016/j.molcel.2023.07.013",

language = "English (US)",

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T2 - Orchestrating pyrimidine biosynthesis and ferroptosis defense

AU - Gan, Boyi

PY - 2023/8/17

Y1 - 2023/8/17

N2 - A recent study by Yang et al.1 uncovers the pyrimidinosome, a multienzyme complex where enzymes from different subcellular compartments collaborate to enable efficient pyrimidine biosynthesis and ferroptosis defense, highlighting the remarkable adaptability of cellular metabolism and new therapeutic opportunities.

AB - A recent study by Yang et al.1 uncovers the pyrimidinosome, a multienzyme complex where enzymes from different subcellular compartments collaborate to enable efficient pyrimidine biosynthesis and ferroptosis defense, highlighting the remarkable adaptability of cellular metabolism and new therapeutic opportunities.

UR - http://www.scopus.com/inward/record.url?scp=85167602151&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85167602151&partnerID=8YFLogxK

U2 - 10.1016/j.molcel.2023.07.013

DO - 10.1016/j.molcel.2023.07.013

M3 - Comment/debate

C2 - 37595553

AN - SCOPUS:85167602151

SN - 1097-2765

VL - 83

SP - 2837

EP - 2839

JO - Molecular cell

JF - Molecular cell

IS - 16

ER -

The pyrimidinosome: Orchestrating pyrimidine biosynthesis and ferroptosis defense

Abstract

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