The RCAS-TVA system for introduction of oncogenes into selected somatic mammary epithelial cells in vivo

Jay P. Reddy; Yi Li

doi:10.1007/s10911-009-9157-1

The RCAS-TVA system for introduction of oncogenes into selected somatic mammary epithelial cells in vivo

Jay P. Reddy, Yi Li

Research output: Contribution to journal › Review article › peer-review

15 Scopus citations

Abstract

We have reported the use of the RCAS-TVA system to model sporadic tumorigenesis upon oncogenic activation in somatic mammary epithelial cells in the mouse. Here we review the advantages of this approach as compared to conventional mouse models with transgenic oncogene expression. We also in detail describe the RCAS-TVA method for introducing genes into somatic mammary epithelial cells engineered to express the avian receptor tva. This method may be particularly useful in modeling oncogenic activation and subsequent tumorigenesis in distinct breast epithelial cell sub-populations, including progenitor cells.

Original language	English (US)
Pages (from-to)	405-409
Number of pages	5
Journal	Journal of Mammary Gland Biology and Neoplasia
Volume	14
Issue number	4
DOIs	https://doi.org/10.1007/s10911-009-9157-1
State	Published - Dec 2009
Externally published	Yes

Keywords

Breast cancer
Mammary gland
RCAS
Somatic cell
Tva

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1007/s10911-009-9157-1

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title = "The RCAS-TVA system for introduction of oncogenes into selected somatic mammary epithelial cells in vivo",

abstract = "We have reported the use of the RCAS-TVA system to model sporadic tumorigenesis upon oncogenic activation in somatic mammary epithelial cells in the mouse. Here we review the advantages of this approach as compared to conventional mouse models with transgenic oncogene expression. We also in detail describe the RCAS-TVA method for introducing genes into somatic mammary epithelial cells engineered to express the avian receptor tva. This method may be particularly useful in modeling oncogenic activation and subsequent tumorigenesis in distinct breast epithelial cell sub-populations, including progenitor cells.",

keywords = "Breast cancer, Mammary gland, RCAS, Somatic cell, Tva",

author = "Reddy, {Jay P.} and Yi Li",

note = "Funding Information: Acknowledgments We thank Drs. Michael Lewis and Gary Chamness for critical review of this manuscript. This work was supported in part by the National Institutes of Health grant CA113869 (to Y.L.).",

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T1 - The RCAS-TVA system for introduction of oncogenes into selected somatic mammary epithelial cells in vivo

AU - Reddy, Jay P.

AU - Li, Yi

N1 - Funding Information: Acknowledgments We thank Drs. Michael Lewis and Gary Chamness for critical review of this manuscript. This work was supported in part by the National Institutes of Health grant CA113869 (to Y.L.).

PY - 2009/12

Y1 - 2009/12

N2 - We have reported the use of the RCAS-TVA system to model sporadic tumorigenesis upon oncogenic activation in somatic mammary epithelial cells in the mouse. Here we review the advantages of this approach as compared to conventional mouse models with transgenic oncogene expression. We also in detail describe the RCAS-TVA method for introducing genes into somatic mammary epithelial cells engineered to express the avian receptor tva. This method may be particularly useful in modeling oncogenic activation and subsequent tumorigenesis in distinct breast epithelial cell sub-populations, including progenitor cells.

AB - We have reported the use of the RCAS-TVA system to model sporadic tumorigenesis upon oncogenic activation in somatic mammary epithelial cells in the mouse. Here we review the advantages of this approach as compared to conventional mouse models with transgenic oncogene expression. We also in detail describe the RCAS-TVA method for introducing genes into somatic mammary epithelial cells engineered to express the avian receptor tva. This method may be particularly useful in modeling oncogenic activation and subsequent tumorigenesis in distinct breast epithelial cell sub-populations, including progenitor cells.

KW - Breast cancer

KW - Mammary gland

KW - RCAS

KW - Somatic cell

KW - Tva

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JO - Journal of Mammary Gland Biology and Neoplasia

JF - Journal of Mammary Gland Biology and Neoplasia

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The RCAS-TVA system for introduction of oncogenes into selected somatic mammary epithelial cells in vivo

Abstract

Keywords

ASJC Scopus subject areas

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