The role and therapeutic targeting of JAK/STAT signaling in glioblastoma

Alexander Ou; Martina Ott; Dexing Fang; Amy B. Heimberger

doi:10.3390/cancers13030437

The role and therapeutic targeting of JAK/STAT signaling in glioblastoma

Alexander Ou, Martina Ott, Dexing Fang, Amy B. Heimberger

Research output: Contribution to journal › Review article › peer-review

60 Scopus citations

Abstract

Glioblastoma remains one of the deadliest and treatment-refractory human malignancies in large part due to its diffusely infiltrative nature, molecular heterogeneity, and capacity for immune escape. The Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathway contributes substantively to a wide variety of protumorigenic functions, including proliferation, anti-apoptosis, angiogenesis, stem cell maintenance, and immune suppression. We review the current state of knowledge regarding the biological role of JAK/STAT signaling in glioblastoma, therapeutic strategies, and future directions for the field.

Original language	English (US)
Article number	437
Pages (from-to)	1-25
Number of pages	25
Journal	Cancers
Volume	13
Issue number	3
DOIs	https://doi.org/10.3390/cancers13030437
State	Published - Feb 1 2021

Keywords

Glioblastoma
Immunotherapy
JAK
Resistance
STAT3

ASJC Scopus subject areas

Oncology
Cancer Research

Access to Document

10.3390/cancers13030437

Cite this

@article{ceef4f3ae68e47c79ab7f8e6f70a6bb3,

title = "The role and therapeutic targeting of JAK/STAT signaling in glioblastoma",

abstract = "Glioblastoma remains one of the deadliest and treatment-refractory human malignancies in large part due to its diffusely infiltrative nature, molecular heterogeneity, and capacity for immune escape. The Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathway contributes substantively to a wide variety of protumorigenic functions, including proliferation, anti-apoptosis, angiogenesis, stem cell maintenance, and immune suppression. We review the current state of knowledge regarding the biological role of JAK/STAT signaling in glioblastoma, therapeutic strategies, and future directions for the field.",

keywords = "Glioblastoma, Immunotherapy, JAK, Resistance, STAT3",

author = "Alexander Ou and Martina Ott and Dexing Fang and Heimberger, {Amy B.}",

note = "Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2021",

month = feb,

day = "1",

doi = "10.3390/cancers13030437",

language = "English (US)",

volume = "13",

pages = "1--25",

journal = "Cancers",

issn = "2072-6694",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "3",

}

TY - JOUR

T1 - The role and therapeutic targeting of JAK/STAT signaling in glioblastoma

AU - Ou, Alexander

AU - Ott, Martina

AU - Fang, Dexing

AU - Heimberger, Amy B.

PY - 2021/2/1

Y1 - 2021/2/1

N2 - Glioblastoma remains one of the deadliest and treatment-refractory human malignancies in large part due to its diffusely infiltrative nature, molecular heterogeneity, and capacity for immune escape. The Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathway contributes substantively to a wide variety of protumorigenic functions, including proliferation, anti-apoptosis, angiogenesis, stem cell maintenance, and immune suppression. We review the current state of knowledge regarding the biological role of JAK/STAT signaling in glioblastoma, therapeutic strategies, and future directions for the field.

AB - Glioblastoma remains one of the deadliest and treatment-refractory human malignancies in large part due to its diffusely infiltrative nature, molecular heterogeneity, and capacity for immune escape. The Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathway contributes substantively to a wide variety of protumorigenic functions, including proliferation, anti-apoptosis, angiogenesis, stem cell maintenance, and immune suppression. We review the current state of knowledge regarding the biological role of JAK/STAT signaling in glioblastoma, therapeutic strategies, and future directions for the field.

KW - Glioblastoma

KW - Immunotherapy

KW - JAK

KW - Resistance

KW - STAT3

UR - http://www.scopus.com/inward/record.url?scp=85099977658&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85099977658&partnerID=8YFLogxK

U2 - 10.3390/cancers13030437

DO - 10.3390/cancers13030437

M3 - Review article

C2 - 33498872

AN - SCOPUS:85099977658

SN - 2072-6694

VL - 13

SP - 1

EP - 25

JO - Cancers

JF - Cancers

IS - 3

M1 - 437

ER -

The role and therapeutic targeting of JAK/STAT signaling in glioblastoma

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this