The role of bisphosphonates in medical oncology and their association with jaw bone necrosis

Ahmed Eid; Jennifer Atlas

doi:10.1016/j.coms.2014.01.009

The role of bisphosphonates in medical oncology and their association with jaw bone necrosis

Ahmed Eid, Jennifer Atlas

General Oncology

Research output: Contribution to journal › Review article › peer-review

8 Scopus citations

Abstract

Bisphosphonates, synthetic analogues to inorganic pyrophosphates found in the bone matrix, inhibit bone resorption. Bisphosphonates and their related effects on the jaw have been established since 2001. The pathogenesis of bisphosphonate-related osteonecrosis of the jaw (BRONJ) is multifactorial and still under investigation. Currently, drugs with mechanisms of action involving remodeling suppression, osteoclast depression, and decreasing angiogenesis are under investigation for causing BRONJ-like symptoms. Further studies are needed to determine the effective length of use of biphosponates and the efficacy of drug holidays to prevent BRONJ.

Original language	English (US)
Pages (from-to)	231-237
Number of pages	7
Journal	Oral and Maxillofacial Surgery Clinics of North America
Volume	26
Issue number	2
DOIs	https://doi.org/10.1016/j.coms.2014.01.009
State	Published - May 2014

Keywords

Bisphosphonate-related osteonecrosis of the jaw
Bisphosphonates
Cancer
Jaw bone necrosis
Multiple myeloma
Oncology

ASJC Scopus subject areas

Surgery
Oral Surgery
Otorhinolaryngology

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10.1016/j.coms.2014.01.009

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abstract = "Bisphosphonates, synthetic analogues to inorganic pyrophosphates found in the bone matrix, inhibit bone resorption. Bisphosphonates and their related effects on the jaw have been established since 2001. The pathogenesis of bisphosphonate-related osteonecrosis of the jaw (BRONJ) is multifactorial and still under investigation. Currently, drugs with mechanisms of action involving remodeling suppression, osteoclast depression, and decreasing angiogenesis are under investigation for causing BRONJ-like symptoms. Further studies are needed to determine the effective length of use of biphosponates and the efficacy of drug holidays to prevent BRONJ.",

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AU - Eid, Ahmed

AU - Atlas, Jennifer

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AB - Bisphosphonates, synthetic analogues to inorganic pyrophosphates found in the bone matrix, inhibit bone resorption. Bisphosphonates and their related effects on the jaw have been established since 2001. The pathogenesis of bisphosphonate-related osteonecrosis of the jaw (BRONJ) is multifactorial and still under investigation. Currently, drugs with mechanisms of action involving remodeling suppression, osteoclast depression, and decreasing angiogenesis are under investigation for causing BRONJ-like symptoms. Further studies are needed to determine the effective length of use of biphosponates and the efficacy of drug holidays to prevent BRONJ.

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KW - Cancer

KW - Jaw bone necrosis

KW - Multiple myeloma

KW - Oncology

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The role of bisphosphonates in medical oncology and their association with jaw bone necrosis

Abstract

Keywords

ASJC Scopus subject areas

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