TY - JOUR
T1 - The Role of Cytotoxic Therapy with Hematopoietic Stem Cell Transplantation in the Therapy of Acute Myelogenous Leukemia in Adults
T2 - An Evidence-Based Review
AU - Oliansky, Denise M.
AU - Appelbaum, Frederick
AU - Cassileth, Peter A.
AU - Keating, Armand
AU - Kerr, Jamie
AU - Nieto, Yago
AU - Stewart, Susan
AU - Stone, Richard M.
AU - Tallman, Martin S.
AU - McCarthy, Philip L.
AU - Hahn, Theresa
PY - 2008/2
Y1 - 2008/2
N2 - Clinical research examining the role of hematopoietic stem cell transplantation (HSCT) in the therapy of acute myelogenous leukemia (AML) in adults is presented and critically evaluated in this systematic evidence-based review. Specific criteria were used for searching the published literature and for grading the quality and strength of the evidence and the strength of the treatment recommendations. Treatment recommendations based on the evidence are presented in Table 3, entitled Summary of Treatment Recommendations Made by the Expert Panel for Adult Acute Myelogenous Leukemia, and were reached unanimously by a panel of AML experts. The identified priority areas of needed future research in adult AML include: (1) What is the role of HSCT in treating patients with specific molecular markers (eg, FLT3, NPM1, CEBPA, BAALC, MLL, NRAS, etc.) especially in patients with normal cytogenetics? (2) What is the benefit of using HSCT to treat different cytogenetic subgroups? (3) What is the impact on survival outcomes of reduced intensity or nonmyeloablative versus conventional conditioning in older (>60 years) and intermediate (40-60 years) aged adults? (4) What is the impact on survival outcomes of unrelated donor HSCT vesus chemotherapy in younger (<40 years) adults with high risk disease?
AB - Clinical research examining the role of hematopoietic stem cell transplantation (HSCT) in the therapy of acute myelogenous leukemia (AML) in adults is presented and critically evaluated in this systematic evidence-based review. Specific criteria were used for searching the published literature and for grading the quality and strength of the evidence and the strength of the treatment recommendations. Treatment recommendations based on the evidence are presented in Table 3, entitled Summary of Treatment Recommendations Made by the Expert Panel for Adult Acute Myelogenous Leukemia, and were reached unanimously by a panel of AML experts. The identified priority areas of needed future research in adult AML include: (1) What is the role of HSCT in treating patients with specific molecular markers (eg, FLT3, NPM1, CEBPA, BAALC, MLL, NRAS, etc.) especially in patients with normal cytogenetics? (2) What is the benefit of using HSCT to treat different cytogenetic subgroups? (3) What is the impact on survival outcomes of reduced intensity or nonmyeloablative versus conventional conditioning in older (>60 years) and intermediate (40-60 years) aged adults? (4) What is the impact on survival outcomes of unrelated donor HSCT vesus chemotherapy in younger (<40 years) adults with high risk disease?
KW - Acute myeloid leukemia
KW - Adult
KW - Hematopoietic stem cell transplantation
KW - Therapy
UR - http://www.scopus.com/inward/record.url?scp=38349194178&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=38349194178&partnerID=8YFLogxK
U2 - 10.1016/j.bbmt.2007.11.002
DO - 10.1016/j.bbmt.2007.11.002
M3 - Review article
C2 - 18215777
AN - SCOPUS:38349194178
SN - 1083-8791
VL - 14
SP - 137
EP - 180
JO - Biology of Blood and Marrow Transplantation
JF - Biology of Blood and Marrow Transplantation
IS - 2
ER -