The role of deubiquitinating enzymes in chromatin regulation

Boyko S. Atanassov; Evangelia Koutelou; Sharon Y. Dent

doi:10.1016/j.febslet.2010.10.042

The role of deubiquitinating enzymes in chromatin regulation

Boyko S. Atanassov, Evangelia Koutelou, Sharon Y. Dent

Epigenetics & Molecular Carcinogenesis

Research output: Contribution to journal › Review article › peer-review

61 Scopus citations

Abstract

Post-translational modifications of the histones are centrally involved in the regulation of all DNA-templated processes, including gene transcription, DNA replication, recombination, and repair. These modifications are often dynamic, and their removal is just as important as their addition in proper regulation of cellular functions. Although histone acetylation/deacetylation and histone methylation/demethylation are highly studied, the functions and regulation of histone ubiquitination and deubiquitination are less well understood. This review highlights our current understanding of how histone ubiquitination impacts gene transcription, DNA repair, and cell cycle progression, and stresses the importance of deubiquitinases to normal cellular functions as well as to disease states such as cancer.

Original language	English (US)
Pages (from-to)	2016-2023
Number of pages	8
Journal	FEBS Letters
Volume	585
Issue number	13
DOIs	https://doi.org/10.1016/j.febslet.2010.10.042
State	Published - Jul 7 2011

Keywords

Cell cycle
Chromatin
Deubiquitination
Histones
Transcriptional regulation

ASJC Scopus subject areas

Biophysics
Structural Biology
Biochemistry
Molecular Biology
Genetics
Cell Biology

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10.1016/j.febslet.2010.10.042

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abstract = "Post-translational modifications of the histones are centrally involved in the regulation of all DNA-templated processes, including gene transcription, DNA replication, recombination, and repair. These modifications are often dynamic, and their removal is just as important as their addition in proper regulation of cellular functions. Although histone acetylation/deacetylation and histone methylation/demethylation are highly studied, the functions and regulation of histone ubiquitination and deubiquitination are less well understood. This review highlights our current understanding of how histone ubiquitination impacts gene transcription, DNA repair, and cell cycle progression, and stresses the importance of deubiquitinases to normal cellular functions as well as to disease states such as cancer.",

keywords = "Cell cycle, Chromatin, Deubiquitination, Histones, Transcriptional regulation",

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AU - Koutelou, Evangelia

AU - Dent, Sharon Y.

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N2 - Post-translational modifications of the histones are centrally involved in the regulation of all DNA-templated processes, including gene transcription, DNA replication, recombination, and repair. These modifications are often dynamic, and their removal is just as important as their addition in proper regulation of cellular functions. Although histone acetylation/deacetylation and histone methylation/demethylation are highly studied, the functions and regulation of histone ubiquitination and deubiquitination are less well understood. This review highlights our current understanding of how histone ubiquitination impacts gene transcription, DNA repair, and cell cycle progression, and stresses the importance of deubiquitinases to normal cellular functions as well as to disease states such as cancer.

AB - Post-translational modifications of the histones are centrally involved in the regulation of all DNA-templated processes, including gene transcription, DNA replication, recombination, and repair. These modifications are often dynamic, and their removal is just as important as their addition in proper regulation of cellular functions. Although histone acetylation/deacetylation and histone methylation/demethylation are highly studied, the functions and regulation of histone ubiquitination and deubiquitination are less well understood. This review highlights our current understanding of how histone ubiquitination impacts gene transcription, DNA repair, and cell cycle progression, and stresses the importance of deubiquitinases to normal cellular functions as well as to disease states such as cancer.

KW - Cell cycle

KW - Chromatin

KW - Deubiquitination

KW - Histones

KW - Transcriptional regulation

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The role of deubiquitinating enzymes in chromatin regulation

Abstract

Keywords

ASJC Scopus subject areas

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