The role of exosomal microRNAs in pancreatic cancer

Yifan Xu; Xiaohui Xu; Abigael Williams; Weiqun Ding

doi:10.21037/SCI.2020.02.01

The role of exosomal microRNAs in pancreatic cancer

Yifan Xu, Xiaohui Xu, Abigael Williams, Weiqun Ding

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Pancreatic cancer is the third leading cause of cancer death in the United States. New therapeutic and diagnostic strategies are urgently needed to improve pancreatic cancer outcomes. Exosomes are endosome-derived extracellular vesicles containing cellular lipids, proteins, and microRNAs (miRNAs). Studies have shown that exosomal miRNAs are potential diagnostic biomarkers and therapeutic targets for various types of cancer. In this review, we summarize recent findings indicating the role of exosomal miRNAs in pancreatic cancer progression, therapeutic resistance, and biomarker development.

Original language	English (US)
Journal	Stem Cell Investigation
Volume	7
DOIs	https://doi.org/10.21037/SCI.2020.02.01
State	Published - 2020
Externally published	Yes

Keywords

Biomarker
Chemoresistance
Exosome
Microrna (mirna)
Pancreatic cancer

ASJC Scopus subject areas

Molecular Biology
Genetics
Developmental Biology
Cell Biology

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10.21037/SCI.2020.02.01

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title = "The role of exosomal microRNAs in pancreatic cancer",

abstract = "Pancreatic cancer is the third leading cause of cancer death in the United States. New therapeutic and diagnostic strategies are urgently needed to improve pancreatic cancer outcomes. Exosomes are endosome-derived extracellular vesicles containing cellular lipids, proteins, and microRNAs (miRNAs). Studies have shown that exosomal miRNAs are potential diagnostic biomarkers and therapeutic targets for various types of cancer. In this review, we summarize recent findings indicating the role of exosomal miRNAs in pancreatic cancer progression, therapeutic resistance, and biomarker development.",

keywords = "Biomarker, Chemoresistance, Exosome, Microrna (mirna), Pancreatic cancer",

author = "Yifan Xu and Xiaohui Xu and Abigael Williams and Weiqun Ding",

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language = "English (US)",

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T1 - The role of exosomal microRNAs in pancreatic cancer

AU - Xu, Yifan

AU - Xu, Xiaohui

AU - Williams, Abigael

AU - Ding, Weiqun

PY - 2020

Y1 - 2020

N2 - Pancreatic cancer is the third leading cause of cancer death in the United States. New therapeutic and diagnostic strategies are urgently needed to improve pancreatic cancer outcomes. Exosomes are endosome-derived extracellular vesicles containing cellular lipids, proteins, and microRNAs (miRNAs). Studies have shown that exosomal miRNAs are potential diagnostic biomarkers and therapeutic targets for various types of cancer. In this review, we summarize recent findings indicating the role of exosomal miRNAs in pancreatic cancer progression, therapeutic resistance, and biomarker development.

AB - Pancreatic cancer is the third leading cause of cancer death in the United States. New therapeutic and diagnostic strategies are urgently needed to improve pancreatic cancer outcomes. Exosomes are endosome-derived extracellular vesicles containing cellular lipids, proteins, and microRNAs (miRNAs). Studies have shown that exosomal miRNAs are potential diagnostic biomarkers and therapeutic targets for various types of cancer. In this review, we summarize recent findings indicating the role of exosomal miRNAs in pancreatic cancer progression, therapeutic resistance, and biomarker development.

KW - Biomarker

KW - Chemoresistance

KW - Exosome

KW - Microrna (mirna)

KW - Pancreatic cancer

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JO - Stem Cell Investigation

JF - Stem Cell Investigation

ER -

The role of exosomal microRNAs in pancreatic cancer

Abstract

Keywords

ASJC Scopus subject areas

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