TY - JOUR
T1 - The role of extracellular vesicles in cancer
AU - Kalluri, Raghu
AU - McAndrews, Kathleen M.
N1 - Publisher Copyright:
© 2023 Elsevier Inc.
PY - 2023/4/13
Y1 - 2023/4/13
N2 - Intercellular communication is a key feature of cancer progression and metastasis. Extracellular vesicles (EVs) are generated by all cells, including cancer cells, and recent studies have identified EVs as key mediators of cell-cell communication via packaging and transfer of bioactive constituents to impact the biology and function of cancer cells and cells of the tumor microenvironment. Here, we review recent advances in understanding the functional contribution of EVs to cancer progression and metastasis, as cancer biomarkers, and the development of cancer therapeutics.
AB - Intercellular communication is a key feature of cancer progression and metastasis. Extracellular vesicles (EVs) are generated by all cells, including cancer cells, and recent studies have identified EVs as key mediators of cell-cell communication via packaging and transfer of bioactive constituents to impact the biology and function of cancer cells and cells of the tumor microenvironment. Here, we review recent advances in understanding the functional contribution of EVs to cancer progression and metastasis, as cancer biomarkers, and the development of cancer therapeutics.
UR - http://www.scopus.com/inward/record.url?scp=85151571030&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85151571030&partnerID=8YFLogxK
U2 - 10.1016/j.cell.2023.03.010
DO - 10.1016/j.cell.2023.03.010
M3 - Review article
C2 - 37059067
AN - SCOPUS:85151571030
SN - 0092-8674
VL - 186
SP - 1610
EP - 1626
JO - Cell
JF - Cell
IS - 8
ER -