TY - JOUR
T1 - The Role of Immunotherapy in the Treatment of Rare Central Nervous System Tumors
AU - Rodriguez, Andrew
AU - Kamiya-Matsuoka, Carlos
AU - Majd, Nazanin K.
N1 - Publisher Copyright:
© 2023 by the authors.
PY - 2023/6
Y1 - 2023/6
N2 - Establishing novel therapies for rare central nervous system (CNS) tumors is arduous due to challenges in conducting clinical trials in rare tumors. Immunotherapy treatment has been a rapidly developing field and has demonstrated improvements in outcomes for multiple types of solid malignancies. In rare CNS tumors, the role of immunotherapy is being explored. In this article, we review the preclinical and clinical data of various immunotherapy modalities in select rare CNS tumors, including atypical meningioma, aggressive pituitary adenoma, pituitary carcinoma, ependymoma, embryonal tumor, atypical teratoid/rhabdoid tumor, and meningeal solitary fibrous tumor. Among these tumor types, some studies have shown promise; however, ongoing clinical trials will be critical for defining and optimizing the role of immunotherapy for these patients.
AB - Establishing novel therapies for rare central nervous system (CNS) tumors is arduous due to challenges in conducting clinical trials in rare tumors. Immunotherapy treatment has been a rapidly developing field and has demonstrated improvements in outcomes for multiple types of solid malignancies. In rare CNS tumors, the role of immunotherapy is being explored. In this article, we review the preclinical and clinical data of various immunotherapy modalities in select rare CNS tumors, including atypical meningioma, aggressive pituitary adenoma, pituitary carcinoma, ependymoma, embryonal tumor, atypical teratoid/rhabdoid tumor, and meningeal solitary fibrous tumor. Among these tumor types, some studies have shown promise; however, ongoing clinical trials will be critical for defining and optimizing the role of immunotherapy for these patients.
KW - central nervous system tumors
KW - immunotherapy
KW - rare
KW - treatment
UR - http://www.scopus.com/inward/record.url?scp=85163732179&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85163732179&partnerID=8YFLogxK
U2 - 10.3390/curroncol30060401
DO - 10.3390/curroncol30060401
M3 - Review article
C2 - 37366884
AN - SCOPUS:85163732179
SN - 1198-0052
VL - 30
SP - 5279
EP - 5298
JO - Current Oncology
JF - Current Oncology
IS - 6
ER -