The role of integrins in tumor angiogenesis

Rosa Hwang; Judy Varner

doi:10.1016/j.hoc.2004.09.010

The role of integrins in tumor angiogenesis

Rosa Hwang, Judy Varner

Research output: Contribution to journal › Review article › peer-review

91 Scopus citations

Abstract

Integrins are cell adhesion molecules that play an important role in the regulation of angiogenesis. In this overview, the vascular integrins and their mechanisms of action are outlined. Integrins have been evaluated in preclinical and clinical studies for the treatment of cancer and as diagnostic markers of angiogenesis. Furthermore, integrins are the basis for targeted therapy for solid tumors and novel imaging techniques to assess the angiogenic response of tumors.

Original language	English (US)
Pages (from-to)	991-1006
Number of pages	16
Journal	Hematology/Oncology Clinics of North America
Volume	18
Issue number	5
DOIs	https://doi.org/10.1016/j.hoc.2004.09.010
State	Published - Oct 2004
Externally published	Yes

ASJC Scopus subject areas

Hematology
Oncology

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10.1016/j.hoc.2004.09.010

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abstract = "Integrins are cell adhesion molecules that play an important role in the regulation of angiogenesis. In this overview, the vascular integrins and their mechanisms of action are outlined. Integrins have been evaluated in preclinical and clinical studies for the treatment of cancer and as diagnostic markers of angiogenesis. Furthermore, integrins are the basis for targeted therapy for solid tumors and novel imaging techniques to assess the angiogenic response of tumors.",

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AB - Integrins are cell adhesion molecules that play an important role in the regulation of angiogenesis. In this overview, the vascular integrins and their mechanisms of action are outlined. Integrins have been evaluated in preclinical and clinical studies for the treatment of cancer and as diagnostic markers of angiogenesis. Furthermore, integrins are the basis for targeted therapy for solid tumors and novel imaging techniques to assess the angiogenic response of tumors.

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The role of integrins in tumor angiogenesis

Abstract

ASJC Scopus subject areas

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