TY - JOUR
T1 - The role of JAK pathway dysregulation in the pathogenesis and treatment of acute myeloid leukemia
AU - Lee, Hun Ju
AU - Daver, Naval
AU - Kantarjian, Hagop M.
AU - Verstovsek, Srdan
AU - Ravandi, Farhad
PY - 2013/1/15
Y1 - 2013/1/15
N2 - The discovery of the Janus kinase 2 (JAK2) V617F mutation has improved our understanding of the pathophysiology of myeloproliferative neoplasms such as polycythemia vera, essential thrombocythemia, and primary myelofibrosis. Before discovery of the JAK2 V617F mutation, there were no specific targeted therapies for patients with myeloproliferative neoplasms.More recently, several small-molecule inhibitors have been developed that have shown therapeutic potential in the clinical setting. There is evidence that the JAK2 pathway is dysregulated in some acutemyeloid leukemias and may also represent a novel therapeutic target in this disease. In this review, we describe the preclinical, clinical, and pathophysiologic evidence for using JAK inhibitors in the treatment of acute myeloid leukemias.
AB - The discovery of the Janus kinase 2 (JAK2) V617F mutation has improved our understanding of the pathophysiology of myeloproliferative neoplasms such as polycythemia vera, essential thrombocythemia, and primary myelofibrosis. Before discovery of the JAK2 V617F mutation, there were no specific targeted therapies for patients with myeloproliferative neoplasms.More recently, several small-molecule inhibitors have been developed that have shown therapeutic potential in the clinical setting. There is evidence that the JAK2 pathway is dysregulated in some acutemyeloid leukemias and may also represent a novel therapeutic target in this disease. In this review, we describe the preclinical, clinical, and pathophysiologic evidence for using JAK inhibitors in the treatment of acute myeloid leukemias.
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U2 - 10.1158/1078-0432.CCR-12-2087
DO - 10.1158/1078-0432.CCR-12-2087
M3 - Review article
C2 - 23209034
AN - SCOPUS:84872554955
SN - 1078-0432
VL - 19
SP - 327
EP - 335
JO - Clinical Cancer Research
JF - Clinical Cancer Research
IS - 2
ER -