The role of LKB1 and AMPK in cellular responses to stress and damage

Angela Alexander; Cheryl L. Walker

doi:10.1016/j.febslet.2011.03.010

The role of LKB1 and AMPK in cellular responses to stress and damage

Angela Alexander, Cheryl L. Walker

Experimental Radiation Oncology

Research output: Contribution to journal › Review article › peer-review

124 Scopus citations

Abstract

The LKB1 and AMPK proteins participate in an energy sensing cascade that responds to depletion of ATP, serving as a master regulator of metabolism that inhibits anabolic processes and stimulates catabolic processes. However in recent years, LKB1 and AMPK have been implicated in a variety of other cellular processes, both cytoplasmic and nuclear, such as control of cell polarity and regulation of gene transcription. In this review, we summarize the most recent discoveries regarding participation of LKB1 and AMPK in signaling pathways that respond to cellular stress and damage, and the relevance of this signaling for disease and therapy.

Original language	English (US)
Pages (from-to)	952-957
Number of pages	6
Journal	FEBS Letters
Volume	585
Issue number	7
DOIs	https://doi.org/10.1016/j.febslet.2011.03.010
State	Published - Apr 6 2011

Keywords

AMPK
Apoptosis
DNA damage
LKB1
Stress
Survival

ASJC Scopus subject areas

Biophysics
Structural Biology
Biochemistry
Molecular Biology
Genetics
Cell Biology

Access to Document

10.1016/j.febslet.2011.03.010

Cite this

@article{69746f9afab6448381e18e18b253b1bf,

title = "The role of LKB1 and AMPK in cellular responses to stress and damage",

abstract = "The LKB1 and AMPK proteins participate in an energy sensing cascade that responds to depletion of ATP, serving as a master regulator of metabolism that inhibits anabolic processes and stimulates catabolic processes. However in recent years, LKB1 and AMPK have been implicated in a variety of other cellular processes, both cytoplasmic and nuclear, such as control of cell polarity and regulation of gene transcription. In this review, we summarize the most recent discoveries regarding participation of LKB1 and AMPK in signaling pathways that respond to cellular stress and damage, and the relevance of this signaling for disease and therapy.",

keywords = "AMPK, Apoptosis, DNA damage, LKB1, Stress, Survival",

author = "Angela Alexander and Walker, {Cheryl L.}",

note = "Funding Information: This work was supported by grants from NIH (to C.L.W.), the Ovarian Cancer Research Foundation (to C.L.W.) and the Sowell-Huggins Fellowship (to A.A.).",

year = "2011",

month = apr,

day = "6",

doi = "10.1016/j.febslet.2011.03.010",

language = "English (US)",

volume = "585",

pages = "952--957",

journal = "FEBS Letters",

issn = "0014-5793",

publisher = "Elsevier",

number = "7",

}

TY - JOUR

T1 - The role of LKB1 and AMPK in cellular responses to stress and damage

AU - Alexander, Angela

AU - Walker, Cheryl L.

N1 - Funding Information: This work was supported by grants from NIH (to C.L.W.), the Ovarian Cancer Research Foundation (to C.L.W.) and the Sowell-Huggins Fellowship (to A.A.).

PY - 2011/4/6

Y1 - 2011/4/6

N2 - The LKB1 and AMPK proteins participate in an energy sensing cascade that responds to depletion of ATP, serving as a master regulator of metabolism that inhibits anabolic processes and stimulates catabolic processes. However in recent years, LKB1 and AMPK have been implicated in a variety of other cellular processes, both cytoplasmic and nuclear, such as control of cell polarity and regulation of gene transcription. In this review, we summarize the most recent discoveries regarding participation of LKB1 and AMPK in signaling pathways that respond to cellular stress and damage, and the relevance of this signaling for disease and therapy.

AB - The LKB1 and AMPK proteins participate in an energy sensing cascade that responds to depletion of ATP, serving as a master regulator of metabolism that inhibits anabolic processes and stimulates catabolic processes. However in recent years, LKB1 and AMPK have been implicated in a variety of other cellular processes, both cytoplasmic and nuclear, such as control of cell polarity and regulation of gene transcription. In this review, we summarize the most recent discoveries regarding participation of LKB1 and AMPK in signaling pathways that respond to cellular stress and damage, and the relevance of this signaling for disease and therapy.

KW - AMPK

KW - Apoptosis

KW - DNA damage

KW - LKB1

KW - Stress

KW - Survival

UR - http://www.scopus.com/inward/record.url?scp=79953236022&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79953236022&partnerID=8YFLogxK

U2 - 10.1016/j.febslet.2011.03.010

DO - 10.1016/j.febslet.2011.03.010

M3 - Review article

C2 - 21396365

AN - SCOPUS:79953236022

SN - 0014-5793

VL - 585

SP - 952

EP - 957

JO - FEBS Letters

JF - FEBS Letters

IS - 7

ER -

The role of LKB1 and AMPK in cellular responses to stress and damage

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this